Clinical utility of chromosomal microarray in establishing clonality and high risk features in patients with Richter transformation
| Autor: | Lindsey Hendrickson, Iya Znoyko, James Kalmuk, Daynna J. Wolff, Irl Brian Greenwell, Zane Chiad, Cynthia A. Schandl, Sandra Mazzoni, Nina D. Wagner-Johnston, Brian T. Hess |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Microarray Chronic lymphocytic leukemia Aggressive lymphoma Biology Genomic Instability law.invention Randomized controlled trial CDKN2A law hemic and lymphatic diseases Internal medicine Genetics medicine Chromosomes Human Humans Molecular Biology Aged Retrospective Studies Richter transformation Microarray analysis techniques Middle Aged Microarray Analysis Prognosis medicine.disease Leukemia Lymphocytic Chronic B-Cell Clone Cells Lymphoma Disease Progression Female Lymphoma Large B-Cell Diffuse |
| Zdroj: | Cancer Genetics. :18-22 |
| ISSN: | 2210-7762 |
| DOI: | 10.1016/j.cancergen.2021.10.003 |
| Popis: | Richter transformation (RT) refers to the development of an aggressive lymphoma in patients with pre-existing chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). It carries a poor prognosis secondary to poor response to therapy or rapid disease relapse. Currently there are no randomized trials to guide treatment. Therapeutic decisions are often influenced by the presence or absence of a clonal relationship between the underlying CLL/SLL and the new lymphoma given the poor prognosis of patients with clonally related RT. Chromosomal microarray analysis (CMA) can help to establish clonality while also detecting genomic complexity and clinically relevant genetic variants such as loss of CDKN2A and/or TP53. As a result, CMA has potential prognostic and therapeutic implications. For this study, CMA results from patients with Richter transformation were evaluated in paired CLL/SLL and transformed lymphoma samples. CMA revealed that 86% of patients had common aberrations in the two samples indicating evidence of common clonality. CMA was also useful in detecting aberrations associated with a poor prognosis in 71% of patients with RT. This study highlights the potential clinical utility of CMA to investigate the clonal relationship between CLL/SLL and RT, provide prognostic information, and possibly guide therapeutic decision making for patients with Richter transformation. |
| Databáze: | OpenAIRE |
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