Incomplete hippocampal inversion in schizophrenia: prevalence, severity, and impact on hippocampal structure
| Autor: | Stephan Heckers, Maureen McHugo, Simon N. Vandekar, Maxwell J Roeske, Jennifer Urbano Blackford, Neil D. Woodward |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Automated segmentation Hippocampus Hippocampal formation behavioral disciplines and activities Lateralization of brain function Article 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Internal medicine Healthy control mental disorders medicine Prevalence Humans Molecular Biology business.industry Human brain medicine.disease Magnetic Resonance Imaging Hippocampal structure Causality Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure Schizophrenia Cardiology business 030217 neurology & neurosurgery |
| Zdroj: | Mol Psychiatry |
| Popis: | Incomplete hippocampal inversion (IHI) is an anatomical variant of the human brain resulting from an arrest in brain development, especially prevalent in the left hemisphere. We hypothesized that IHI is more common in schizophrenia and contributes to the well-known hippocampal structural differences. We studied 199 schizophrenia patients and 161 healthy control participants with 3 T MRI to establish IHI prevalence and the relationship of IHI with hippocampal volume and asymmetry. IHI was more prevalent (left hemisphere: 15% of healthy control participants, 27% of schizophrenia patients; right hemisphere: 4% of healthy control participants, 10% of schizophrenia patients) and more severe in schizophrenia patients compared to healthy control participants. Severe IHI cases were associated with a higher rate of automated segmentation failure. IHI contributed to smaller hippocampal volume and increased R > L volume asymmetry in schizophrenia. The increased prevalence and severity of IHI supports the neurodevelopmental model of schizophrenia. The impact of this developmental variant deserves further exploration in studies of the hippocampus in schizophrenia. |
| Databáze: | OpenAIRE |
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