Isolated distant lymph node metastases in ovarian cancer. Should a new substage be created?
| Autor: | Emily M. Ko, Mark A. Morgan, Robert A. Burger, A.F. Haggerty, Robert L. Giuntoli, Nawar A. Latif, Dimitrios Nasioudis |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty Pathological staging lcsh:Gynecology and obstetrics lcsh:RC254-282 Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Case Series Stage IIIC Stage (cooking) Stage IV Lymph nodes lcsh:RG1-991 Cancer 030219 obstetrics & reproductive medicine Proportional hazards model business.industry Ovary Obstetrics and Gynecology lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease 030220 oncology & carcinogenesis Distant Lymph Node Ovarian cancer business |
| Zdroj: | Gynecologic Oncology Reports Gynecologic Oncology Reports, Vol 28, Iss, Pp 86-90 (2019) |
| ISSN: | 2352-5789 |
| DOI: | 10.1016/j.gore.2019.03.008 |
| Popis: | Abstact Objective To evaluate the prognostic significance of isolated distant lymph node metastases in comparison to other metastatic sites and stage IIIC disease. Methods The National Cancer Data Base was accessed and patients diagnosed between 2004 and 2014 with stage IV or IIIC epithelial ovarian cancer who met criteria for pathological staging were identified. Overall survival (OS) was calculated with Kaplan-Meier curves and compared with the log-rank test. A Cox model was constructed to control for confounders. Results A total of 33,561 patients met the inclusion criteria; 582 (1.7%) had stage IV only due to distant lymph node metastases (stage IV-LN), 8130 (24.2%) had stage IV with other sites of distant metastases (stage IV-other) and 24,849 (75.4%) had stage IIIC disease. The median OS for patients with stage IV-LN was 42.41 months (95% CI: 37.59, 47.23) compared to 30.23 months (95% CI: 29.30, 31.16) for those with stage IV-other (p Highlights • Stage IV due to isolated distant lymph node metastasis is rare. • These patients had better survival compared to those with stage IV disease due to other metastases. • Their survival was comparable to patients with stage IIIC disease. |
| Databáze: | OpenAIRE |
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