Reactivity of Cortical Alpha Rhythms to Eye Opening in Mild Cognitive Impairment and Alzheimer's Disease: an EEG Study

Autor: Michela Pievani, Giovanni B. Frisoni, Roberta Lizio, Bartolo Lanuzza, Fracassi Claudia, Paolo Maria Rossini, Claudio Babiloni, Cristina Geroldi, Raffaele Ferri, Fabrizio Vecchio
Rok vydání: 2011
Předmět:
Male
medicine.medical_specialty
Rest
Alpha (ethology)
Disease
Neuropsychological Tests
Electroencephalography
Audiology
Brain mapping
eyes-closed resting state
Alzheimer's disease
amnesic mild cognitive impairment
and alpha rhythms
delta
electroencephalography
eyes-open resting state
low resolution brain electromagnetic tomography (LORETA)
theta
Aged
Alpha Rhythm
Alzheimer Disease
Amnesia
Analysis of Variance
Brain Mapping
Cerebral Cortex
Cognition Disorders
Female
Humans
Middle Aged
Ocular Physiological Phenomena
Psychiatry and Mental Health
Geriatrics and Gerontology
Clinical Psychology
Alpha rhythm
medicine
Reactivity (psychology)
medicine.diagnostic_test
General Neuroscience
General Medicine
Psychiatry and Mental health
Alpha-2 adrenergic receptor
Analysis of variance
Psychology
Neuroscience
Zdroj: Journal of Alzheimer's Disease. 22:1047-1064
ISSN: 1875-8908
1387-2877
DOI: 10.3233/jad-2010-100798
Popis: Cortical sources of resting eyes-closed alpha rhythms are typically abnormal in mild cognitive impairment (MCI) and Alzheimer's disease (AD) subjects. Here we tested the hypothesis of a progressive impairment of cortical alpha reactivity to eye-opening across amnesic MCI and mild AD subjects, reflecting another aspect of the impairment of cortical neural synchronization. Resting electroencephalography (EEG) data were recorded in 36 normal elderly subjects (Nold), 91 amnesic MCI, and 31 mild AD subjects during eyes-closed and -open conditions. EEG sources were estimated by LORETA software. In the eye-closed condition, posterior alpha 1 (8-10.5 Hz) sources were lower in MCI and AD than Nold subjects. The opposite was true for occipital delta sources (2-4 Hz). Reactivity to the eyes-open condition showed posterior alpha 1 and alpha 2 (10.5-13 Hz) sources was high in the Nold, intermediate in the MCI, and low in the AD subjects. Furthermore, occipital alpha 1 reactivity across MCI and AD subjects was correlated to the cognitive impairment as revealed by Mini-Mental State Examination score. In conclusion, at least at group level, the continuum across amnesic MCI and mild AD status is related to an impaired reactivity of cortical neuronal synchronization to eyes opening at alpha rhythms.
Databáze: OpenAIRE
Externí odkaz: