Astrocytic outer retinal layer thinning is not a feature in AQP4-IgG seropositive neuromyelitis optica spectrum disorders

Autor: Maria Isabel Leite, Letizia Leocani, Jérôme De Seze, Denis Bernardi Bichuetti, Ibis Soto de Castillo, Sasitorn Siritho, Alvaro Cobo-Calvo, Elena H. Martinez-Lapiscina, Anitha D'Cunha, Adriana Roca-Fernandez, Jacqueline Palace, Orhan Aktas, Marco Aurélio Lana-Peixoto, Marco Pisa, Michael R. Yeaman, Anu Jacob, Mariana Andrade Fontenelle, Friedemann Paul, Ari J. Green, Yang Mao-Draayer, Eugene F May, Claudia Chien, Alireza Dehghani, Ivan Maynart Tavares, Lawrence J. Cook, Angelo Lu, Su-Kyung Jung, Rengin Yildirim, Ayse Altintas, Mohsen Pourazizi, Ho Jin Kim, Rahele Kafieh, Caryl Tongco, Lekha Pandit, Hadas Stiebel-Kalish, Romain Marignier, Fereshteh Ashtari, Hanna Zimmermann, Joachim Havla, M. Radaelli, Svenja Specovius, Frederike C. Oertel, Kerstin Soelberg, Srilakshmi M Sharma, Axel Petzold, Seyedamirhosein Motamedi, Zoe Rimler, Saif Huda, Philipp Albrecht, Alexander U. Brandt, Jae-Won Hyun, Allyson Reid, Marius Ringelstein, Uygur Tanriverdi, Terry J. Smith, Thomas Senger, Nasrin Asgari, Charlotte Bereuter
Přispěvatelé: Altıntaş, Ayşe (ORCID 0000-0002-8524-5087 & YÖK ID 11611), Lu, A., Zimmermann, HG., Specovius, S., Motamedi, S., Chien, C., Bereuter, C., Lana-Peixoto, MA., Fontenelle, MA., Ashtari, F., Kafieh, R., Dehghani, A., Pourazizi, M., Pandit, L., D Cunha, A., Kim, HJ., Hyun, JW., Jung, SK., Leocani, L., Pisa, M., Radaelli, M., Siritho, S., May, E.F., Tongco, C., De Sèze, J., Senger, T., Palace, J., Roca-Fernández, A., Leite, MI., Sharma, SM., Stiebel-Kalish, H., Asgari, N., Soelberg, K.K., Martinez-Lapiscina, EH., Havla, J., Mao-Draayer, Y., Rimler, Z., Reid, A., Marignier, R., Cobo-Calvo, A., Tanriverdi, U., Yildirim, R., Aktas, O., Ringelstein, M., Albrecht, P., Tavares, IM., Bichuetti, DB., Jacob, A., Huda, S., Soto de Castillo, I., Petzold, A., Green, AJ., Yeaman, MR., Smith, TJ., Cook, L., Paul, F., Brandt, AU., Oertel, FC., GJCF International Clinical Consortium for NMOSD., Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine, Neurology, Ophthalmology, APH - Mental Health, APH - Methodology, Amsterdam Neuroscience - Neuroinfection & -inflammation
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Neurology, Neurosurgery, and Psychiatry
Journal of neurology, neurosurgery, and psychiatry, 93(2), 188-195. BMJ Publishing Group
GJCF International Clinical Consortium for NMOSD 2022, ' Astrocytic outer retinal layer thinning is not a feature in AQP4-IgG seropositive neuromyelitis optica spectrum disorders ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 93, no. 2, pp. 188-195 . https://doi.org/10.1136/jnnp-2021-327412
Lu, A, Zimmermann, H G, Specovius, S, Motamedi, S, Chien, C, Bereuter, C, Lana-Peixoto, M A, Fontenelle, M A, Ashtari, F, Kafieh, R, Dehghani, A, Pourazizi, M, Pandit, L, D'Cunha, A, Kim, H J, Hyun, J-W, Jung, S-K, Leocani, L, Pisa, M, Radaelli, M, Siritho, S, May, E F, Tongco, C, de Sèze, J R, Senger, T, Palace, J, Roca-Fernández, A, Leite, M I, Sharma, S M, Stiebel-Kalish, H, Asgari, N, Soelberg, K K, Martinez-Lapiscina, E H, Havla, J, Mao-Draayer, Y, Rimler, Z, Reid, A, Marignier, R, Cobo-Calvo, A, Altintas, A, Tanriverdi, U, Yildirim, R, Aktas, O, Ringelstein, M, Albrecht, P, Tavares, I M, Bichuetti, D B, Jacob, A, Huda, S, Soto de Castillo, I, Petzold, A, Green, A J, Yeaman, M R, Smith, T J, Cook, L, Paul, F, GJCF International Clinical Consortium for NMOSD, Brandt, A U & Oertel, F C 2022, ' Astrocytic outer retinal layer thinning is not a feature in AQP4-IgG seropositive neuromyelitis optica spectrum disorders ', Journal of neurology, neurosurgery, and psychiatry, vol. 93, no. 2, pp. 188-195 . https://doi.org/10.1136/jnnp-2021-327412
ISSN: 0022-3050
Popis: Background: patients with anti-aquaporin-4 antibody seropositive (AQP4-IgG+) neuromyelitis optica spectrum disorders (NMOSDs) frequently suffer from optic neuritis (ON) leading to severe retinal neuroaxonal damage. Further, the relationship of this retinal damage to a primary astrocytopathy in NMOSD is uncertain. Primary astrocytopathy has been suggested to cause ON-independent retinal damage and contribute to changes particularly in the outer plexiform layer (OPL) and outer nuclear layer (ONL), as reported in some earlier studies. However, these were limited in their sample size and contradictory as to the localisation. This study assesses outer retinal layer changes using optical coherence tomography (OCT) in a multicentre cross-sectional cohort. Method: 197 patients who were AQP4-IgG+ and 32 myelin-oligodendrocyte-glycoprotein antibody seropositive (MOG-IgG+) patients were enrolled in this study along with 75 healthy controls. Participants underwent neurological examination and OCT with central postprocessing conducted at a single site. Results: no significant thinning of OPL (25.02 +/- 2.03 mu m) or ONL (61.63 +/- 7.04 mu m) were observed in patients who were AQP4-IgG+ compared with patients who were MOG-IgG+ with comparable neuroaxonal damage (OPL: 25.10 +/- 2.00 mu m; ONL: 64.71 +/- 7.87 mu m) or healthy controls (OPL: 24.58 +/- 1.64 mu m; ONL: 63.59 +/- 5.78 mu m). Eyes of patients who were AQP4-IgG+ (19.84 +/- 5.09 mu m, p=0.027) and MOG-IgG+ (19.82 +/- 4.78 mu m, p=0.004) with a history of ON showed parafoveal OPL thinning compared with healthy controls (20.99 +/- 5.14 mu m); this was not observed elsewhere. Conclusion: the results suggest that outer retinal layer loss is not a consistent component of retinal astrocytic damage in AQP4-IgG+ NMOSD. Longitudinal studies are necessary to determine if OPL and ONL are damaged in late disease due to retrograde trans-synaptic axonal degeneration and whether outer retinal dysfunction occurs despite any measurable structural correlates.
Guthy Jackson Charitable Foundation (GJCF); German Research Foundation (DFG)
Databáze: OpenAIRE
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