Susceptibility to Influenza A Virus Infection in Mice Immunosuppressed with Cyclophosphamide

Autor: M G Premrov, Sandro Grelli, Cartesio Favalli, Antonio Mastino
Rok vydání: 1991
Předmět:
0301 basic medicine
Premedication
medicine.disease_cause
Mice
0302 clinical medicine
Immunologic
Influenza A virus
Killer Cells
Pharmacology (medical)
Non-U.S. Gov't
Influenzavirus
Inbred BALB C
Cytotoxicity Tests
Mice
Inbred BALB C
article
Settore MED/07 - Microbiologia e Microbiologia Clinica
Killer Cells
Natural
Infectious Diseases
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Natural
Disease Susceptibility
Viral disease
Support
cyclophosphamide
animal experiment
immune deficiency
influenza
influenza virus a
intraperitoneal drug administration
mouse
nonhuman
Animal
Cyclophosphamide
Cytotoxicity Tests
Immunologic
Immunosuppression
Lymphocyte Subsets
Orthomyxoviridae Infections
Spleen
Support
Non-U.S. Gov't
medicine.drug
030106 microbiology
Orthomyxoviridae
Biology
Virus
Natural killer cell
03 medical and health sciences
Immune system
medicine
Animals
Immunosuppression Therapy
Pharmacology
biology.organism_classification
Virology
Immunology
Zdroj: Journal of Chemotherapy. 3:156-161
ISSN: 1973-9478
1120-009X
DOI: 10.1080/1120009x.1991.11739084
Popis: It is known that immunocompromised hosts show an enhanced susceptibility to microbial infections. Among these, viral infections represent a particular problem because of the lack of really efficient antiviral drugs. In the present report we have studied the effect of pharmacological immunosuppression with cyclophosphamide (CY) in virus infection in vivo, using Balb/c mice infected with influenza A virus (PR8). At the dose of 0.1 hemagglutinating units of viral inoculum, intranasal administration of PR8 virus caused the death of 50 to 60% of the animals within a period of 3-10 days. A single injection of CY (200 mg/kg) significantly increased mouse mortality to 90%, when PR8 virus challenge was performed 4 days after chemotherapy pretreatment. When the PR8 virus infection was performed at different times after CY-treatment, a similar appreciable effect was not observed. Severe alterations of some immunological parameters such as NK activity and analysis of lymphoid spleen cell subsets were related to the increased susceptibility to virus infection.
Databáze: OpenAIRE
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