Metabolism of Fibrinogen in Patients with Rheumatoid Arthritis and in a Control Group
| Autor: | R. Bach Andersen, Th. Friis |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Male
Wrist Joint medicine.medical_specialty Knee Joint Immunology Fibrinogen Gastroenterology Injections Intra-Articular Arthritis Rheumatoid Iodine Radioisotopes Rheumatology Internal medicine medicine Humans Immunology and Allergy In patient Plasma Volume Aged business.industry Blood Proteins General Medicine Metabolism Middle Aged medicine.disease Resorption Inflamed joints Turnover Rheumatoid arthritis Female business Half-Life medicine.drug |
| Zdroj: | Acta Rheumatologica Scandinavica. 17:94-104 |
| ISSN: | 0001-6934 |
| DOI: | 10.3109/rhe1.1971.17.issue-1-4.15 |
| Popis: | SummaryI131-fibrinogen turnover rate was examined in 27 patients, 15 patients with RA and 12 patients with various diseases. Fractional catabolic rate was identical in the two groups and a difference was found only in the mass of fibrinogen g/day, mean turnover being twice as high in the RA. In countings of radioactivity of the inflamed joints, a correlation to activity of the disease was found. Intraarticular injection of I131-tagged fibrinogen into two patients with RA, and into two patients with no joint complaints showed some deviation in proportion of “clot”/plasma activity. In RA patients a tendency to resorption of fibrinogen from the joint was observed and in the controls a tendency to local lysis. |
| Databáze: | OpenAIRE |
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