An Advanced Formulation of a Magnesium Dietary Supplement Adapted for a Long-Term Use Supplementation Improves Magnesium Bioavailability: In Vitro and Clinical Comparative Studies

Autor: Christian Duale, Jean-Michel Cardot, Claude Dubray, Gisèle Pickering, Anna Trzeciakiewicz, Elodie Martin, Fabienne Joanny
Přispěvatelé: CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, CIC Clermont Ferrand, Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-Centre de Pharmacologie Clinique, Neuro-Dol (Neuro-Dol), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Microbiologie Environnement Digestif Santé (MEDIS), INRA Clermont-Ferrand-Theix-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Image Science for Interventional Techniques (ISIT), Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS)-Clermont Université, Neurologie et thérapeutique expérimentale, Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR70-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d’Investigation Clinique (CIC), FJ LIFE SCIENCES, Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR70-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2018
Předmět:
Adult
Male
0301 basic medicine
Absorption (pharmacology)
Adolescent
improved absorption
Endocrinology
Diabetes and Metabolism
continuous release
Clinical Biochemistry
Dietary supplement
Biological Availability
chemistry.chemical_element
long-term supplementation
Biochemistry
magnesium element
Inorganic Chemistry
Young Adult
03 medical and health sciences
Double-Blind Method
[SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication
Healthy volunteers
Humans
Magnesium
Food science
High absorption
Cross-Over Studies
030109 nutrition & dietetics
Chemistry
Biochemistry (medical)
magnesium chloride
General Medicine
Low magnesium
Middle Aged
Healthy Volunteers
3. Good health
Bioavailability
low dose
Dietary Supplements
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Digestive tract
Zdroj: Biological Trace Element Research
Biological Trace Element Research, Humana Press, 2018, 186 (1), pp.1-8. ⟨10.1007/s12011-018-1277-2⟩
Biological Trace Element Research, 2018, 186 (1), pp.1-8. ⟨10.1007/s12011-018-1277-2⟩
ISSN: 1559-0720
0163-4984
Popis: International audience; While general recommendations are for 300-mg magnesium intake a day, an advanced low-dose formulation of magnesium chloride, ChronoMag (R), was designed to provide 100mg of magnesium element, thus decreasing the risk of gastrointestinal side effects and allowing long-term supplementation in health conditions related to low magnesium levels. The present study aimed to compare magnesium release profile and bioavailability between this patented low-dose continuous-release magnesium chloride tablet (100mg magnesium element) and a reference tablet at the usually prescribed dose (300mg magnesium element). Magnesium release profile was determined by dissolving the tablets in solutions simulating the gastrointestinal tract environment. A randomized double-blind crossover controlled trial of ChronoMag (R) versus reference tablet (3x100mg magnesium element tablets) in 12 normo-magnesemic healthy volunteers was conducted to evaluate the bioavailability of the patented magnesium chloride tablets (two 50mg magnesium tablets, once-a-day intake). While the reference tablet released 100% of its magnesium within 1h of dissolution, release from the magnesium chloride formulation was continuous for 6h. Cumulative urinary magnesium levels compared to those with the reference tablet were 76% (0-5h), 89% (0-10h), and 87% (0-24h). Elimination after 24h was fairly similar with both supplements. Our results suggest that the new magnesium chloride formulation, providing continuous low-dose magnesium release throughout the gastrointestinal tract, improves absorption and bioavailability. This formulation conforms to the physiological mechanism of magnesium absorption throughout the digestive tract, allowing high absorption, and may improve gastrointestinal tolerance in long-term use.
Databáze: OpenAIRE
Externí odkaz: