The effect of bariatric surgery on inflammatory markers in women with polycystic ovarian syndrome

Autor: Firass Abiad, Johnny Awwad, Dalia Khalife, Fatin Khalifeh, Bassem Y. Safadi, Ramzi S. Alami, Ghina Ghazeeri
Rok vydání: 2018
Předmět:
Adult
Sleeve gastrectomy
medicine.medical_specialty
endocrine system diseases
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Bariatric Surgery
030209 endocrinology & metabolism
03 medical and health sciences
Young Adult
0302 clinical medicine
Insulin resistance
Weight loss
Diabetes mellitus
Statistical significance
Sex Hormone-Binding Globulin
Weight Loss
Internal Medicine
medicine
Genetic predisposition
Humans
Insulin
Testosterone
Obesity
Prospective Studies
030219 obstetrics & reproductive medicine
Adiponectin
Anthropometry
business.industry
nutritional and metabolic diseases
General Medicine
medicine.disease
female genital diseases and pregnancy complications
Rate of increase
Surgery
C-Reactive Protein
Case-Control Studies
Body Composition
Female
medicine.symptom
business
Biomarkers
Polycystic Ovary Syndrome
Zdroj: Diabetesmetabolic syndrome. 12(6)
ISSN: 1878-0334
Popis: Aim The aims of this study is to address the improvement in CRP and adiponectin in obese PCOS and non PCOS after bariatric surgery, and to show that obese PCOS women have a slower rate of improvement when compared to obese non PCOS women. Methods This is a prospective case-control study evaluating the effect of weight loss by sleeve gastrectomy among obese PCOS patients. Results There was a 36.28% of weight loss among obese PCOS and 33.04% among the control group at 12 months. Both groups showed a significant increase in the adiponectin levels at 3, 6 and 12 months’ post-surgery. The rate of increase was higher in the obese non PCOS women (4.93 ± 1.79–9.79 ± 3.9) compared to obese PCOS women (5.05 ± 1.98–7.25 ± 0.21). The CRP levels decreased with weight loss after the surgery to reach statistical significance at 3 months in obese PCOS group (4.18 ± 3.94, p = 0.048). Conclusion The degree of weight loss after surgery was effective in lowering CRP and increasing adiponectin levels in PCOS women. However, this improvement was slower compared to obese non PCOS patients. A genetic predisposition to insulin resistance might explain these findings.
Databáze: OpenAIRE
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