Motor-neuron-disease-like phenotype associated with IgLON5 disease

Autor:	Sri Raghav Sista, Brian Crum, Albert Aboseif, Michelle F. Devine, Anastasia Zekeridou, M. Bakri Hammami, Mohammed M. Rezk, André Truffert, Patrice H. Lalive, Amy Kunchok, Andrew McKeon, Divyanshu Dubey
Rok vydání:	2022
Předmět:	Motor Neurons Phenotype Neurology Cell Adhesion Molecules Neuronal Immunoglobulin G Amyotrophic Lateral Sclerosis Humans Neurology (clinical) Motor Neuron Disease Immunosuppressive Agents Autoantibodies
Zdroj:	Journal of Neurology. 269:6139-6144
ISSN:	1432-1459 0340-5354
Popis:	A growing spectrum of neurological manifestations are being recognized in association with IgLON5 autoimmunity, including recent reports of motor-neuron-disease-like phenotype. Here we describe four cases of IgLON5 autoimmunity with motor neuron involvement and evaluate an additional 109 probable or definite amyotrophic lateral sclerosis cases seen in our neuromuscular clinic for IgLON5-IgG seropositivity. The presence of parasomnias, vocal cord dysfunction or hyperkinetic movements in a patient with motor-neuron-disease-like phenotype should prompt evaluation for IgLON5-IgG autoantibodies. Recognition and treatment of this autoimmune disease with immunosuppressive agents may bring about significant neurological improvement in a minority of cases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1698b14832c8b030e18275b9e71350a https://doi.org/10.1007/s00415-022-11262-0 Zobrazit plný text záznamu Full text from SpringerLink