COVID-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era

Autor: Claudia Fortuny, Manel Juan, Laia Alsina, L. Yiyi, Ana Esteve-Solé, A. Deyà-Martínez, Cristian Launes, M. Español, Iolanda Jordan, Vicky Fumado, Alexandru Vlagea, A. García-García, Mariona Pascal, E.A. Gonzalez-Navarro
Rok vydání: 2021
Předmět:
Male
Pediatrics
Cross-sectional study
Primary immunodeficiency disease
Children
COVID-19
Prevalence
Immunology and Allergy
Medicine
Young adult
Prospective cohort study
Child
PBL
peripheral blood lymphocytes
education.field_of_study
CID
combined immunodeficiency
HSCT
hematopoietic stem cell transplant
PBMC
peripheral blood mononuclear cells
SCID
severe combined immunodeficiency
ESID
European Society of Immunodeficiencies
Child
Preschool
Female
medicine.symptom
CVID
common variable immunodeficiency
medicine.medical_specialty
Adolescent
Primary Immunodeficiency Diseases
Immunology
Population
Protective factor
PBS
phosphate-buffered saline
Inborn errors immunity
Asymptomatic
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
WHO
World Health Organization
CMC
chronic mucocutaneous candidiasis
Young Adult
Full Length Article
WHIM
(warts
hypogammaglobulinemia
immunodeficiency
myelokatexis)
Humans
Risk factor
education
IEI
inborn errors of immunity
PHA
phytohemaglutinin
RT-PCR
real-time-PCR
IgRT
immunoglobulin replacement treatment
business.industry
SARS-CoV-2
CGD
chronic granulomatous disease
TMB
tetramethylbenzidine
COVID-19
Infant
ACE-II
angiotensin-converting enzyme II
Cross-Sectional Studies
El Niño
business
Zdroj: CLINICAL IMMUNOLOGY
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Clinical Immunology (Orlando, Fla.)
ISSN: 1521-6616
Popis: Background Information regarding inborn error of immunity (IEI) as a risk factor for severe COVID-19 is scarce. We aimed to determine if paediatric patients with moderate/severe IEI got COVID-19 at the same level as the general population, and to describe COVID-19 expression. Material and methods We included patients with moderate/severe IEI aged 0–21 years old: cross-sectional study (June2020) to determine the prevalence of COVID-19; prospective study (January2020-January2021) including IEI patients with COVID-19. Assays used: nasopharyngeal swab SARS-CoV-2 PCR and SARS-CoV-2-specific immunoglobulins. Results Seven from sixty-five patients tested positive (prevalence: 10.7% (7%–13%)) after the first SARS-COV-2 wave and 13/15 patients diagnosed with COVID-19 had an asymptomatic/mild course. Conclusions In our area, prevalence of COVID-19 in moderate/severe IEI paediatric patients after the first wave was slightly higher than in the general population. The majority of patients presented a benign course, suggesting a possible protective factor related with age despite IEI.
Databáze: OpenAIRE
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