Multiple sclerosis and solar exposure before the age of 15 years: case—control study in Cuba, Martinique and Sicily
| Autor: | François Dalmay, JA Cabrera-Gómez, Devender Bhalla, Alessandra Nicoletti, Michel Dumas, F. Ruiz, Michel Druet-Cabanac, P. Cabre, Pierre-Marie Preux |
|---|---|
| Přispěvatelé: | Neuroépidémiologie Tropicale et Comparée (NETEC), Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Université de Limoges (UNILIM), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Service de Santé au Travail [CHU Limoges], CHU Limoges, Unité Fonctionnelle Registre Général des Cancers du Limousin (UFRGC), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME) |
| Rok vydání: | 2010 |
| Předmět: |
Male
Pediatrics Neurological disorder MESH: Cuba Poser criteria 0302 clinical medicine MESH: Martinique Epidemiology Family history Sicily MESH: Sicily MESH: Aged 0303 health sciences education.field_of_study MESH: Middle Aged Cuba Middle Aged MESH: Case-Control Studies Neurology MESH: Young Adult Sunlight Female Martinique Adult MESH: Sunlight medicine.medical_specialty Multiple Sclerosis Adolescent Ultraviolet Rays Population Young Adult 03 medical and health sciences medicine Humans education Aged 030304 developmental biology MESH: Adolescent MESH: Humans business.industry Multiple sclerosis MESH: Adult MESH: Multiple Sclerosis Odds ratio medicine.disease MESH: Male Case-Control Studies MESH: Ultraviolet Rays [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Neurology (clinical) business MESH: Female 030217 neurology & neurosurgery |
| Zdroj: | Multiple Sclerosis Journal Multiple Sclerosis Journal, SAGE Publications, 2010, 16 (8), pp.899-908. ⟨10.1177/1352458510366856⟩ |
| ISSN: | 1477-0970 1352-4585 |
| DOI: | 10.1177/1352458510366856 |
| Popis: | International audience; Few studies report a protective role of childhood solar exposure to multiple sclerosis. Our objective was to confirm the protective role of childhood solar exposure in multiple sclerosis in Cuba, Martinique and Sicily. This was a matched case- control study, and cases met Poser criteria for clinically, laboratory (definite, probable) multiple sclerosis. Controls were resident population, without neurological disorder, living close to cases (within 100 km), matched for sex, age (+/-5 years), residence before age 15. We recruited 551 subjects during a 1-year period (193 cases, Cuba n = 95, Sicily n = 50, Martinique n = 48; 358 controls). Some (89%) met definite clinical multiple sclerosis criteria (relapsing remitting form (with and without sequel) (74%), secondary progressive (21%), primary progressive (5%)). Odds ratios in a uni-variate analysis were: family history of multiple sclerosis (5.1) and autoimmune disorder (4.0); wearing shirt (3.5), hat (2.7), pants (2.4); sun exposure causing sunburn (1.8); sun exposure duration (1 h more/day; weekends 0.91, weekdays 0.86); bare-chested (0.6); water sports (0.2). Independent factors in the multivariate analysis were family history of multiple sclerosis (4.8 (1.50-15.10)), wearing pants under sunlight (1.9 (1.10-3.20)), sun exposure duration (1 h more/ day, weekdays 0.90 (0.85-0.98), weekends 0.93 (0.87-0.99)), water sports (0.23 (0.13-0.40)). We conclude that outdoor leisure activities in addition to sun exposure reports are associated with a reduced multiple sclerosis risk, with evidence of dose response. |
| Databáze: | OpenAIRE |
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