Influence of testosterone on autotomy in castrated male rats
| Autor: | Su Man Lin, Martin S. Mok, Shen Kou Tsai, Cheng Ming Tsao |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Testosterone propionate medicine.medical_specialty medicine.drug_class Pain General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley chemistry.chemical_compound Internal medicine medicine Animals Testosterone Orchiectomy General Pharmacology Toxicology and Pharmaceutics business.industry General Medicine Nerve injury Rats Endocrinology Nociception chemistry Estrogen Chronic Disease Self Mutilation Sciatic nerve Sciatic Neuropathy medicine.symptom business Autotomy |
| Zdroj: | Life Sciences. 70:2335-2340 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/s0024-3205(02)01519-9 |
| Popis: | Sex-related differences exist in nociception and gonadal steroids influence the analgesic response in animals and humans. As we have shown previously, estrogen could modify autotomy in female rats using the sciatic nerve transection model. To further characterize the relationship between gonadal steroid and nociception, the role of testosterone on autotomy in sciatic nerve sectioned rats was investigated. Twenty male rats were subjected to orchiectomy (ORX). Then ten rats received subcutaneous sesame oil and the other ten were treated with testosterone propionate in sesame oil (TP; 500 microg/day/rat). All the rats underwent sciatic nerve resection in left hind limb. Degree of self-mutilation was measured daily for 8 weeks. TP reinstatement resulted in significantly lower autotomy scores in orchiectomized rats. The results demonstrated that testosterone could modify the autotomy behavior, an indicator of neuropathic pain, in rats after nerve injury. |
| Databáze: | OpenAIRE |
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