Obesity promotes glucocorticoid-dependent muscle atrophy in male C57BL/6J mice
Autor: | Susan V. Brooks, Laura C. Gunder, JeAnna R. Redd, Ayat AL-Tamimi, Dave Bridges, Innocence Harvey, Carol S. Davis |
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Rok vydání: | 2020 |
Předmět: |
0303 health sciences
medicine.medical_specialty Muscle size business.industry 030209 endocrinology & metabolism medicine.disease C57bl 6j Obesity Muscle atrophy 03 medical and health sciences nutrition Atrophy 0302 clinical medicine Endocrinology Insulin resistance Internal medicine Lean body mass Medicine medicine.symptom business Glucocorticoid Dexamethasone 030304 developmental biology medicine.drug |
Popis: | Glucocorticoids promote muscle atrophy by inducing a class of proteins called atrogenes, resulting in reductions in muscle size and strength. In this work, we evaluated whether a mouse model with pre-existing diet-induced obesity had altered glucocorticoid responsiveness. We observed that all animals treated with the synthetic glucocorticoid dexamethasone had reduced strength, but that obesity exacerbated this effect. These changes were concordant with more pronounced reductions in muscle size, particularly in Type II muscle fibers, and potentiated induction of atrogene expression in the obese mice relative to lean mice. Furthermore, we show that the reductions in lean mass do not fully account for the dexamethasone-induced insulin resistance observed in these mice. Together these data suggest that obesity potentiates glucocorticoid-induced muscle atrophy. |
Databáze: | OpenAIRE |
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