Measurement of nitric oxide and 8-isoprostane in exhaled breath of children with atopic eczema
| Autor: | C. Zinelli, Carlo Caffarelli, Adam Jaffe, Jessica Strid, David J. Atherton |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Spirometry Allergy medicine.medical_specialty Adolescent Dermatology Dinoprost Nitric Oxide Gastroenterology Dermatitis Atopic Nitric oxide Atopy chemistry.chemical_compound Predictive Value of Tests Internal medicine medicine Humans Exhaled breath condensate Respiratory system Child Asthma medicine.diagnostic_test business.industry Exhalation respiratory system medicine.disease respiratory tract diseases Breath Tests chemistry Immunology Female Pulmonary Ventilation business Biomarkers |
| Zdroj: | Clinical and Experimental Dermatology. 34:607-612 |
| ISSN: | 1365-2230 0307-6938 |
| Popis: | Summary Background. Children with atopic eczema (AE) are at risk of developing asthma. Airway inflammation has been shown to be present before the onset of clinical asthma. Increased exhalation (forced expiration; FE) of nitric oxide (FENO) and 8-isoprostane seems to be a feature of bronchial inflammation in people with asthma. Aim. To determine whether the exhalation of these two molecules is increased in children with eczema, even in the absence of overt asthma. Methods. In total, 21 children with AE were recruited and compared with healthy controls. A questionnaire was completed to identify respiratory symptoms compatible with asthma. The severity of AE was graded clinically. Spirometry, FENO measurements and exhaled breath condensate collection for 8-isoprostane were performed. Results. The mean level of 8-isoprostane was similar for children with AE (2.33 ± 4.76 pg/mL) and controls (3.37 ± 3.43). FENO was increased in children with AE (mean 64.97 parts per billion) compared with the normal range, even in the absence of respiratory symptoms and in the presence of normal lung function. Conclusions. FENO but not 8-isoprostane levels in exhaled breath condensate are higher in children with AE without asthma. Our finding may indicate a predictive role for FENO for the development of asthma. |
| Databáze: | OpenAIRE |
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