Coexistance of Amyloidosis and Primary Sjögren's Syndrome: An Overview
| Autor: | Alejandra Iturralde-Chavez, Gabriela Hernández-Molina, Miguel Astudillo-Angel, Edgardo Reyes, David Faz-Muñoz |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Amyloid Autoimmunity 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Rheumatology AA amyloidosis medicine Rheumatoid factor Humans Lymphocytes B-cell lymphoma Lung B cell Aged Cell Proliferation Skin business.industry Amyloidosis Hypergammaglobulinemia Middle Aged medicine.disease Lymphoma medicine.anatomical_structure Phenotype Sjogren's Syndrome 030220 oncology & carcinogenesis business Biomarkers |
| Zdroj: | Current rheumatology reviews. 14(3) |
| ISSN: | 1875-6360 |
| Popis: | Background The association of primary Sjogren´s Syndrome (SS) and amyloidosis has been recognized but scarcely assessed. Objective Herein we analyzed the literature regarding this association in order to describe a SS phenotype prone to both conditions. Methods PubMed and CINAHL databases were searched from inception until April 2016 for the keywords: Amyloidosis, amyloid, Sjogren's syndrome and their combinations. Results Most of the cases corresponded to localized amyloidosis mainly at skin and lung, whereas only three cases were systemic. Other places of localized amyloidosis were the kidney, tracheobronchial, tongue, breast, salivary gland and vocal cord. Most of the localized forms corresponded to AL type, whereas AA amyloidosis was uncommon. The diagnosis of amyloidosis followed the SS onset (1-25 years) and in the majority of patients the presence of B cell hyperactivity traduced by hypergammaglobulinemia, positive rheumatoid factor and/or anti-Ro/SSA and anti-La/SSB antibodies were observed. In seven patients, an associated lymphoma was also documented. Conclusion The spectrum of lymphoid proliferation associated with SS extends beyond the classical B cell lymphoma. Localized or systemic amyloidosis might coexist with primary SS. Localized amyloidosis should be suspected in patients with consistently high serologic activity and suggestive lesions. |
| Databáze: | OpenAIRE |
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