Compartmentalization of cells bearing 'rheumatic' cell surface antigens in peripheral blood and tonsils in rheumatic heart disease
| Autor: | Ernest D. Gray, D. Braun, Mohammed Mansour, P. Ferrieri, J. B. Zabriskie, Z. H. Abdin, Sadek Zaher, L. C. Miller, Reda Kamel, W. E. Regelmann, A. Ei Kholy |
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| Rok vydání: | 1987 |
| Předmět: |
Pathology
medicine.medical_specialty Adolescent medicine.drug_class Tonsillitis Palatine Tonsil 030204 cardiovascular system & hematology Monoclonal antibody Palatine tonsil Epitope 03 medical and health sciences 0302 clinical medicine Immune system Antigen medicine Immunology and Allergy Humans Lymphocytes Child biology business.industry Rheumatic Heart Disease medicine.disease 3. Good health Infectious Diseases medicine.anatomical_structure Immunology Antigens Surface biology.protein Rheumatic fever Antibody business 030215 immunology |
| Zdroj: | The Journal of infectious diseases. 155(2) |
| ISSN: | 0022-1899 |
| Popis: | Monoclonal antibodies that recognize "rheumatic" antigens of peripheral blood non-T cells were used to study the compartmentalization of such cells in peripheral blood and tonsils of individuals with rheumatic heart disease (RHD) and suitable control subjects. The peripheral blood of most (71%) of the 42 individuals with RHD contained cells reacting with monoclonal antibody 83S19.23 or 256S.10, whereas these cells were present in only 17% of the 41 control subjects (P less than .02). However, none of 21 individuals with RHD had such cells in their tonsils, although they were present in the tonsils of 50% of the 40 control subjects (P less than .03). These results may reflect a failure in RHD or organ-specific homing of cells with the epitopes recognized by the antibodies. The presence of these cells in tonsils may be important in the immune response to streptococcal pharyngeal infection, and their absence in RHD may be involved in the unusual immune responses characteristic of this disease. |
| Databáze: | OpenAIRE |
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