Changes of blood flow in the adenohypophysis of normal and estrogen pretreated Fisher rats by tamoxifen
| Autor: | Andrzej Stawowy, Jan Jakubowski, Andras A. Kemeny |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Pituitary gland
medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Injections Subcutaneous Diethylstilbestrol Hemodynamics Biology Endocrinology Pituitary Gland Anterior Internal medicine medicine Animals Hyperplasia General Medicine Blood flow Rats Inbred F344 Rats Tamoxifen medicine.anatomical_structure Blood pressure Cerebral blood flow Estrogen Regional Blood Flow Female medicine.drug |
| Zdroj: | Acta endocrinologica. 121(6) |
| ISSN: | 0001-5598 |
| Popis: | Blood flow was measured in the adenohypophysis and in the cerebral cortex of female F344 rats over a period of 90 min using the hydrogen clearance method. Tamoxifen, 1 mg/kg, administered iv reduced the blood flow in the adenohypophysis by 35%, whereas cerebral blood flow and arterial pressure remained unchanged. Seven days sc treatment with tamoxifen (1 mg/kg daily) had no demonstrable effect on blood flow. Anterior pituitary hyperplasia was induced in 15 rats with diethylstilbestrol containing implants. These rats responded to 7 days of sc tamoxifen treatment by 30% increase in adenohypophyseal blood flow. These results suggest that tamoxifen has a different effect on adenohypophysial circulation of the rat depending on whether it is administered in a low- or high-estrogen state. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|