The comparative burden of mild, moderate and severe Fibromyalgia: results from a cross-sectional survey in the United States

Autor: Meghan Hufstader, Gergana Zlateva, Arthi Chandran, Caroline Schaefer, Rebecca Baik, Michael McNett, Don L. Goldenberg, Robert Gerwin
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Adult
Male
Sleep Wake Disorders
medicine.medical_specialty
Fibromyalgia
Adolescent
Cross-sectional study
Hospital Anxiety and Depression Scale
lcsh:Computer applications to medicine. Medical informatics
Severity of Illness Index
Statistics
Nonparametric
Quality of life
Surveys and Questionnaires
Severity of illness
medicine
Health Status Indicators
Humans
Fatigue
Depression (differential diagnoses)
Aged
Demography
Pain Measurement
Depressive Disorder
Sleep disorder
Chi-Square Distribution
business.industry
Research
Public Health
Environmental and Occupational Health
Patient Outcomes Assessment
General Medicine
Middle Aged
medicine.disease
Anxiety Disorders
United States
Cross-Sectional Studies
Burden of Illness
Physical therapy
Quality of Life
Anxiety
Health Resources
lcsh:R858-859.7
Female
medicine.symptom
business
Zdroj: Health and Quality of Life Outcomes, Vol 9, Iss 1, p 71 (2011)
Health and Quality of Life Outcomes
ISSN: 1477-7525
Popis: Background Fibromyalgia (FM) is characterized by chronic, widespread pain, fatigue, and other symptoms; yet few studies have comprehensively assessed its humanistic burden. This observational study evaluates the impact of FM severity on patients' symptoms, health-related quality of life (HRQoL), and productivity in the United States. Methods 203 FM subjects were recruited from 20 physician offices. Subjects completed a questionnaire including the EuroQol 5D (EQ-5D), Fibromyalgia Impact Questionnaire (FIQ), Multidimensional Assessment of Fatigue (MAF), Medical Outcomes Study Sleep Scale (MOS-SS), and Hospital Anxiety and Depression Scale (HADS) and questions about demographics, pain and other symptoms, HRQoL and productivity. FIQ total scores were used to define FM severity, with 0- < 39, 39- < 59, and 59-100, representing mild, moderate, and severe FM, respectively. Sites recorded subjects' clinical characteristics and FM treatment on case report forms using medical records. Summary statistics were calculated for continuous variables and frequency distributions for categorical variables. Differences across FM severity groups were evaluated using the Kruskal-Wallis or Chi-square tests. Statistical significance was evaluated at the 0.05 level. Results Mean (SD) age was 47.9 (10.9); 95% were female. Most (92%) were prescribed medication for FM; 24% and 66% reported moderate and severe FM, respectively. Mean (SD) scores were: 6.3 (2.1) for pain intensity; 0.35 (0.35) for EQ-5D; 30.7 (14.2) for MAF; 57.5 (18.4) for MOS-SS Sleep Problems Index; 10.2 (4.8) for HADS anxiety and 9.4 (4.4) for HADS depression. Subjects with worse FM severity reported significantly increased pain severity, HRQoL, fatigue, sleep disturbance, anxiety and depression (p < 0.001). Overall, 50% of subjects reported some disruption in their employment due to FM; this differed across severity levels (p < 0.001). Employed subjects missed a mean (SD) of 1.8 (3.9) workdays during the past 4 weeks; this also differed across severity levels (p = 0.03). Conclusions FM imposes a substantial humanistic burden on patients in the United States, and leads to substantial productivity loss, despite treatment. This burden is higher among subjects with worse FM severity.
Databáze: OpenAIRE
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