Oxandrolone induced lean mass gain during recovery from severe burns is maintained after discontinuation of the anabolic steroid
| Autor: | Robert H. Demling, Leslie DeSanti |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Weight Gain Critical Care and Intensive Care Medicine Oxandrolone Recovery period Anabolic Agents Thinness Weight loss medicine Humans Nutritional Physiological Phenomena Severe burn business.industry Burn center General Medicine Middle Aged Discontinuation Surgery Body Composition Emergency Medicine Lean body mass Female medicine.symptom Burns business Anabolic steroid medicine.drug |
| Zdroj: | Burns. 29:793-797 |
| ISSN: | 0305-4179 |
| DOI: | 10.1016/j.burns.2003.08.003 |
| Popis: | Weight loss and lean mass loss from burn induced catabolism can be more rapidly restored when the anabolic steroid oxandrolone is added to optimum nutrition compared to nutrition alone. Our purpose in this study was to determine whether the regained lean body mass (LBM) is retained 6 months after stopping oxandrolone. Forty-five severe burn patients, entering the recovery phase were randomized into a nutrition group alone or with the addition of oxandrolone, 20 mg per day upon admission to the acute burn rehabilitation (RH) unit. Oxandrolone was discontinued after at least 80% of the involuntary weight loss occurring in the acute burn period, was restored. Body composition was measured using bioelectric impedence analysis (BIA). We found that patients receiving oxandrolone, in the rehabilitation unit, regained weight and lean mass two to three times faster than with nutrition alone. The difference was statistically significant (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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