Response prediction and treatment tailoring for chronic hepatitis C virus genotype 1 infection
| Autor: | Martin Lagging, Gunnar Norkrans, Magnus Lindh, Rune Wejstål, Thomas Wahlberg, Anders Eilard, Erik Alestig, Johan Westin, Kristoffer Hellstrand, Birgitta Arnholm |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Hepacivirus Hepatitis C virus Alpha interferon Viremia Interferon alpha-2 medicine.disease_cause Gastroenterology Antiviral Agents Polyethylene Glycols chemistry.chemical_compound Pegylated interferon Internal medicine Virology Ribavirin medicine Humans Aged biology business.industry virus diseases Interferon-alpha Hepatitis C Chronic Middle Aged Viral Load biology.organism_classification medicine.disease digestive system diseases Recombinant Proteins Treatment Outcome chemistry Immunology RNA Viral Female Viral disease business Viral load medicine.drug |
| Zdroj: | Journal of clinical microbiology. 45(8) |
| ISSN: | 0095-1137 |
| Popis: | We monitored early viral response during the treatment of hepatitis C virus (HCV) infection with the aim of identifying predictors of treatment outcome. We studied 53 patients with genotype 1 infection who received 180 μg/week pegylated interferon alfa-2a and 1,000 or 1,200 mg/day ribavirin depending on body weight and serially assessed HCV RNA in serum, using the Cobas TaqMan assay. Thirty-one patients (58%) achieved sustained viral response (SVR). SVR was obtained in 100% (10/10) of patients with pretreatment viremia concentrations below 400,000 IU/ml, in 100% (14/14) of patients with more than 1.5 log reduction of HCV RNA after 4 days of treatment, and in 95% (22/23) of patients with a rate of decline in viremia higher than 0.70 log units/week during the second phase. Non-SVR was seen in all patients with a second-phase decline rate lower than 0.35 log units/week. Patients with slopes between 0.50 and 0.80 log units/week achieved SVR (4/4) unless the treatment dose was modified (3/3). We conclude that the second-phase slope appears to be an accurate and useful predictor of treatment response. On the basis of these findings, we propose a model of tailored treatment which takes into account the second-phase slope and the amount of HCV RNA after 21 days of treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|