Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer’s Disease-Like Pathology and Cognitive Impairments
| Autor: | Bin Zhang, Yacoubou Abdoul Razak Mahaman, Jian Bao, Qun Wang, Dan Chen, Fang Huang, Xiaochuan Wang, Maibouge Tanko Mahamane Salissou, Mengjuan Wu, Zhen Wei, Jian-Zhi Wang, Dan Ke, Yuman Wang, Rong Liu |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Pathology Homocysteine medicine.disease_cause Rats Sprague-Dawley Pathogenesis Amyloid beta-Protein Precursor chemistry.chemical_compound 0302 clinical medicine Aspartic Acid Endopeptidases Medicine tau Phosphorylation Moringa oleifera Neurons biology General Neuroscience Neurodegeneration Brain BACE1 Calpain General Medicine Psychiatry and Mental health Clinical Psychology Moringa oleifera (MO) calpain Alzheimer’s disease Research Article Silver Staining medicine.medical_specialty Hyperhomocysteinemia Synapsin I Nerve Tissue Proteins tau Proteins amyloid-β Neuroprotection 03 medical and health sciences Alzheimer Disease Animals Maze Learning Amyloid beta-Peptides Plant Extracts business.industry medicine.disease Peptide Fragments Rats Disease Models Animal Oxidative Stress 030104 developmental biology chemistry biology.protein Amyloid Precursor Protein Secretases Geriatrics and Gerontology Cognition Disorders business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Journal of Alzheimer's Disease |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-180091 |
| Popis: | Alzheimer's disease (AD) is multifactorial with unclear etiopathology. Due to the complexity of AD, many attempted single therapy treatments, like Aβ immunization, have generally failed. Therefore, there is a need for drugs with multiple benefits. Naturally occurring phytochemicals with neuroprotective, anti-amyloidogenic, antioxidative, and anti-inflammatory properties could be a possible way out. In this study, the effect of Moringa oleifera (MO), a naturally occurring plant with high antioxidative, anti-inflammatory, and neuroprotective effects, was evaluated on hyperhomocysteinemia (HHcy) induced AD-like pathology in rats. Homocysteine (Hcy) injection for 14 days was used to induce AD-like pathology. Simultaneous MO extract gavage followed the injection as a preventive treatment or, after injection completion, MO gavage was performed for another 14 days as a curative treatment. MO was found to not only prevent but also rescue the oxidative stress and cognitive impairments induced by Hcy treatment. Moreover, MO recovered the decreased synaptic proteins PSD93, PSD95, Synapsin 1 and Synaptophysin, and improved neurodegeneration. Interestingly, MO decreased the Hyc-induced tau hyperphosphorylation at different sites including S-199, T-231, S-396, and S-404, and at the same time decreased Aβ production through downregulation of BACE1. These effects in HHcy rats were accompanied by a decrease in calpain activity under MO treatment, supporting that calpain activation might be involved in AD pathogenesis in HHcy rats. Taken together, our data, for the first time, provided evidence that MO alleviates tau hyperphosphorylation and Aβ pathology in a HHcy AD rat model. This and previous other studies support MO as a good candidate for, and could provide new insights into, the treatment of AD and other tauopathies. |
| Databáze: | OpenAIRE |
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