Heterogeneous vancomycin resistance in Staphylococcus aureus does not predict development of vancomycin resistance upon vancomycin pressure
| Autor: | Tiphaine Gaillard, Céline Dupieux-Chabert, Marine Butin, Oana Dumitrescu, Oilida Naceur, Caroline Bouveyron, Annie Martra, Michèle Bes, Anne Tristan, François Vandenesch, Gérard Lina, Frédéric Laurent, Jean-Philippe Rasigade |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 77:1032-1035 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/dkab488 |
| Popis: | Background It is unclear whether Staphylococcus aureus with heterogeneous intermediate vancomycin resistance (hVISA) can develop vancomycin resistance faster than vancomycin-susceptible S. aureus (VSSA) strains. Methods We compared the kinetics of vancomycin MIC increase for 15 days of sustained in vitro vancomycin exposure for clinical hVISA (n = 12) and VSSA (n = 24) isolates, as well as for reference strains Mu3 (hVISA) and ATCC 29213 (VSSA). Clinical isolates were categorized as hVISA using the population analysis profile method. MICs were monitored for 15 days and the rate of MIC increase under exposure, for each strain, was evaluated in a linear regression model relative to time. Results All isolates acquired vancomycin resistance upon exposure. Vancomycin MICs increased faster for VSSA compared with hVISA isolates (P < 0.01). Conclusions The hVISA phenotype does not correspond to an enhanced adaptation potential to in vitro vancomycin pressure. |
| Databáze: | OpenAIRE |
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