Association between iron deficiency and febrile seizures
| Autor: | Fenella J. Kirkham, Marina Economou, Miranta Athanassiou-Mataxa, Dimitrios I. Zafeiriou, Panagiotis Kardaras, E. Kontopoulos, Valia Papageorgiou, Euthymia Vargiami |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Transferrin receptor Gastroenterology Seizures Febrile Total iron-binding capacity Recurrence Internal medicine Medicine Humans Prospective Studies Child Mean corpuscular volume medicine.diagnostic_test biology Greece business.industry Transferrin saturation Infant Red blood cell distribution width General Medicine Iron deficiency Iron Deficiencies medicine.disease Ferritin Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Ferritins biology.protein Female Neurology (clinical) Plasma iron business |
| Zdroj: | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. 19(5) |
| ISSN: | 1532-2130 |
| Popis: | ObjectiveThe relationship between iron status and febrile seizures has been examined in various settings, mainly in the Developing World, with conflicting results. The aim of this study was to investigate any association between iron deficiency and febrile seizures (FS) in European children aged 6–60 months.DesignProspective, case–control study.SettingGreek population in Thessaloniki.Patients50 patients with febrile seizures (cases) and 50 controls (children presenting with fever, without seizures).InterventionsNone.Main outcome measuresHaematologic parameters (haemoglobin concentration, haematocrit, mean corpuscular volume, red cell distribution width), plasma iron, total iron-binding capacity, plasma ferritin, transferrin saturation and soluble transferrin receptors were compared in cases and controls.ResultsPlasma ferritin was lower (median [range]: 42.8 (3–285.7) vs 58.3 (21.4–195.3 ng/ml; p = 0.02) and Total Iron Binding Capacity (TIBC) higher (mean [Standard Deviation] 267 [58.9] vs 243 [58.45] ?g/dl, p = 0.04) in cases than in controls. Results were similar for 12 complex FS cases (ferritin 30 (3–121 vs 89 (41.8–141.5 ng/lL; TIBC 292.92 [68.0] vs 232.08 [36.27] ?g/dL). Iron deficiency, defined as ferritin ConclusionsEuropean children with febrile seizures have lower Ferritin than those with fever alone, and iron deficiency, but not anaemia, is associated with recurrence. Iron status screening should be considered as routine for children presenting with or at high risk for febrile seizures. |
| Databáze: | OpenAIRE |
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