Voriconazole topical cream formulation: evidence for stability and antifungal activity

Autor: Philippe-Henri Secrétan, Romain Guery, David Nguyen, Salvatore Cisternino, Fanny Lanternier, Fabrice Vidal, Sylvain Auvity, Olivier Lortholary, Joël Schlatter, Camille Bouchand, Jérémie F. Cohen
Přispěvatelé: CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Mycologie moléculaire - Molecular Mycology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals (CNRMA), Institut Pasteur [Paris] (IP), CCSD, Accord Elsevier, Université de Paris (UP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Génétique et Génomique des Insectes Vecteurs, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Antifungal Agents
MESH: Drug Interactions
[SDV]Life Sciences [q-bio]
Administration
Topical
Skin Cream
Skin infection
0302 clinical medicine
Fusarium
Pharmacology (medical)
Drug Interactions
030212 general & internal medicine
topical
MESH: Arm
Fusarium solani
MESH: Skin Cream
skin infection
MESH: Fusarium
Right forearm
food and beverages
MESH: Voriconazole
General Medicine
3. Good health
MESH: Administration
Topical
[SDV] Life Sciences [q-bio]
Infectious Diseases
Arm
medicine.drug
Microbiology (medical)
Antifungal
Adult
medicine.medical_specialty
medicine.drug_class
030106 microbiology
03 medical and health sciences
Local infection
medicine
Humans
Adverse effect
Voriconazole
MESH: Humans
business.industry
Neurotoxicity
MESH: Adult
stability
MESH: Fusariosis
medicine.disease
MESH: Antifungal Agents
Dermatology
MESH: Male
Topical cream
Fusariosis
fungi
business
Zdroj: International Journal of Antimicrobial Agents
International Journal of Antimicrobial Agents, 2020, 56 (3), pp.106083. ⟨10.1016/j.ijantimicag.2020.106083⟩
International Journal of Antimicrobial Agents, 2020, 56, pp.106083-. ⟨10.1016/j.ijantimicag.2020.106083⟩
ISSN: 1872-7913
0924-8579
DOI: 10.1016/j.ijantimicag.2020.106083⟩
Popis: International audience; Systemic use of voriconazole (VCZ) might be restricted by adverse events, such as hepatotoxicity and neurotoxicity, or drug-drug interactions. Topical VCZ application to skin may help to treat local infection more effectively and limit unwanted whole-body exposure. Topical VCZ cream was stable for 90 days when refrigerated. A patient with cutaneous Fusarium solani infection on his right forearm was successfully treated with topical 1% VCZ cream after failure of oral VCZ treatment.
Databáze: OpenAIRE
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