Soluble Vascular Endothelial Growth Factor Receptor-1 (sVEGFR-1) is Decreased in Lung Cancer Patients Showing Progression: A Pilot Study

Autor:	Alper Sevimli, Mehmet Karadag, Arzu Yilmaztepe, Asuman Tokullugil, Melike Koç, B. Bahadir Erdogan, Berrin Zik, Semra Akgöz, Murat Muhtar Yılmaz, A. Yagci, Engin Ulukaya
Rok vydání:	2007
Předmět:	Adult Male Cancer Research medicine.medical_specialty Pathology Lung Neoplasms Angiogenesis medicine.medical_treatment Pilot Projects Gastroenterology Metastasis chemistry.chemical_compound Reference Values Internal medicine Biomarkers Tumor medicine Humans Lung cancer Receptor Aged Chemotherapy Vascular Endothelial Growth Factor Receptor-1 business.industry Cancer General Medicine Middle Aged medicine.disease Immunohistochemistry Vascular endothelial growth factor Oncology chemistry Disease Progression Female business
Zdroj:	Cancer Investigation. 25:322-327
ISSN:	1532-4192 0735-7907
DOI:	10.1080/07357900701209178
Popis:	Tumor growth and metastasis depend on angiogenesis, and the vascular endothelial growth factor (VEGF) is known to be one of the most important angiogenic factors although the knowledge about its receptors is limited. We, therefore, investigated the treatment-related changes both in the level of the soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) in the serum by ELISA and the expression of VEGFR-1 in cancer tissues by immunohistochemistry. The serum levels were studied in 38 lung cancer patients, and 55 control subjects (21 benign disease and 34 healthy subjects) before the chemotherapy. The treatment-related changes in serum sVEGFR-1 were evaluated in 15 patients 24 and 48 hours after treatment. In addition to serum analysis, the tissue expressions were evaluated in 32 patients before treatment. The treatment-related changes in tissue VEGFR-1 expressions were evaluated in only 12 patients 24 hours after treatment. We observed no significant difference in terms of serum sVEGFR-1 levels between malignant and nonmalignant groups (p > 0.05). There were no significant differences in the levels of sVEGFR-1 before and after treatment (p > 0.05). However, there was a significant difference between sVEGFR-1 levels in the groups (regressive, stable, progressive) classified according to the response to therapy (p = 0.043). A significant difference also was present between the expression levels of tissue VEGFR-1 in the same groups (p = 0.037). As a conclusion, we suggest that prechemotherapy sVEGFR-1 can be helpful for prediction of long-term response to therapy, but it should be studied in larger groups to elucidate its benefit in clinics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a156b02d1e82cbe0c67dbe6b90f7248e https://doi.org/10.1080/07357900701209178 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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