Effect of Hyperbaric Oxygenation on Blood Cytokines and Arginine Derivatives; No Evidence for Induction of Inflammation or Endothelial Injury
| Autor: | Magdalena A. Zabielska-Kaczorowska, Jacek Siewiera, Michał Smoleński, Nils Ludwig, Jacek Kot, Miroslaw J. Szczepanski, Jacek Turyn, Klaudia Brodaczewska, Natalia Jermakow |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Arginine
Angiogenesis medicine.medical_treatment Inflammation Pharmacology Article chemistry.chemical_compound hyperbaric oxygenation Aseptic bone necrosis SDMA Medicine HBOT business.industry General Medicine cytokines Oxygen tension Vascular endothelial growth factor ADMA Cytokine chemistry medicine.symptom business Asymmetric dimethylarginine |
| Zdroj: | Journal of Clinical Medicine, Vol 10, Iss 5488, p 5488 (2021) Journal of Clinical Medicine; Volume 10; Issue 23; Pages: 5488 Journal of Clinical Medicine |
| ISSN: | 2077-0383 |
| Popis: | (1) Background: Hyperbaric oxygen therapy (HBOT) uses 100% oxygen delivered at 1.5–3 times the atmospheric pressure in a specialised chamber to achieve supraphysiological oxygen tension in blood and tissues. Besides its target, HBOT may affect inflammation, endothelial function or angiogenesis. This study analysed the effect of HBOT on blood concentrations of factors that may affect these processes in patients with necrotizing soft-tissue infections (NSTI), aseptic bone necrosis (ABN) and idiopathic sudden sensory neural hearing loss (ISSNHL). (2) Methods: Concentrations asymmetric dimethylarginine (ADMA) and other arginine derivatives were measured with liquid chromatography/mass spectrometry, whereas ELISA was used to quantitate vascular endothelial growth factor (VEGF) and cytokines (IL-1, IL-4, IL-6, IL-10, TGF-β) before and after HBOT in 80 patients (NSTI n = 21, ISSNHL n = 53, ABN n = 6). (3) Results: While some differences were noted between patient groups in ADMA and other arginine derivatives as well as in cytokine concentrations, HBOT did not affect any of these parameters. (4) Conclusions: While cytokines and arginine derivatives concentrations were modified by underlying pathology, hyperbaric oxygenation did not immediately modify it suggesting that it is neutral for inflammation and is not inducing endothelial injury. |
| Databáze: | OpenAIRE |
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