Profiles of inflammatory markers and lipoprotein subclasses in patients undergoing continuous ambulatory peritoneal dialysis
| Autor: | Utako Seino, Yuji Hirowatari, Mika Kon, Takashi Miida, Yuki Horiuchi, Shin Goto, Yuriko Fueki, Hiroki Maruyama, Satoshi Hirayama, Tsuyoshi Ueno, Yoshifumi Fukushima, Hirotoshi Ohmura, Noriaki Iino, Mayumi Idei |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Lipoproteins medicine.medical_treatment Clinical Biochemistry Blood lipids urologic and male genital diseases Biochemistry Gastroenterology Peritoneal dialysis chemistry.chemical_compound High-density lipoprotein Peritoneal Dialysis Continuous Ambulatory Internal medicine medicine Humans Aged Dyslipidemias Inflammation Intermediate-density lipoprotein biology business.industry Biochemistry (medical) Continuous ambulatory peritoneal dialysis C-reactive protein General Medicine Middle Aged medicine.disease female genital diseases and pregnancy complications Cholesterol Endocrinology chemistry Case-Control Studies biology.protein Female lipids (amino acids peptides and proteins) business Biomarkers Dyslipidemia Lipoprotein |
| Zdroj: | Clinica Chimica Acta. 411:1723-1727 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2010.07.016 |
| Popis: | Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) often have inflammation and dyslipidemia that accelerate to atherosclerosis. This study aimed to evaluate chronic inflammation and dyslipidemia in CAPD patients.We measured inflammatory markers and lipoprotein subclasses in 20 CAPD patients (12 men and 8 women, aged 59.5 ± 9.9 y) and 20 gender-matched controls. Lipoproteins were separated by high-performance liquid chromatography (HPLC) using an anion-exchange column.High-sensitivity C-reactive protein and serum amyloid A protein (SAA) were higher among CAPD patients vs. controls (1.6 ± 2.2 vs. 0.8 ± 1.2 mg/l, p0.05; 11.9 ± 12.8 vs. 4.5 ± 2.4 mg/l). HPLC analysis revealed that chylomicron, VLDL, and IDL cholesterol levels were higher among CAPD vs. controls. In contrast, HDL cholesterol was lower among CAPD patients vs. controls. In the subgroup analysis, SAA levels were significantly lower among patients receiving CAPD for3 y than among controls. However, IDL cholesterol was consistently higher among CAPD patients vs. controls.CAPD patients have chronic inflammation and dyslipidemia. IDL cholesterol is the only lipoprotein subclass that is consistently elevated regardless of CAPD duration. More attention should be paid to dyslipidemia in the management of the CAPD patients. |
| Databáze: | OpenAIRE |
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