Uneven Changes In Circulating Blood Cell Counts With Adrenergic Stimulation To The Canine Spleen
| Autor: | Katsuhiko Noguchi, Matao Sakanashi, Toshihiro Matsuzaki, Noboru Shiroma, Yoshihiko Ojiri, Mayuko Sakanashi |
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| Rok vydání: | 2002 |
| Předmět: |
Blood Platelets
Male medicine.medical_specialty Erythrocytes Contraction (grammar) Physiology Spleen Stimulation Blood cell Dogs Receptors Adrenergic alpha-1 Physiology (medical) Internal medicine Isoprenaline Leukocytes medicine Animals Platelet Phenylephrine Pharmacology business.industry Adrenergic Agonists Blood Cell Count medicine.anatomical_structure Sonomicrometry Endocrinology Immunology Female Adrenergic alpha-1 Receptor Agonists business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 29:53-59 |
| ISSN: | 1440-1681 0305-1870 |
| Popis: | SUMMARY 1. Responses of splenic diameter measured by sonomicrometry to α- and β-adrenoceptor stimulants were estimated together with simultaneously measured systemic arterial and splenic venous concentrations of red blood cells (RBC), white blood cells (WBC) and platelets (PLT) in anaesthetized dogs. 2. Intravenous and intrasplenic arterial injections of adrenaline, noradrenaline and phenylephrine all produced profound decreases in splenic diameter. Increases in systemic arterial concentrations of RBC produced by these stimulants were observed immediately following the splenic contraction and marked increases in splenic venous concentration of RBC. 3. Adrenaline and noradrenaline both caused rapid and transient decreases in WBC release from the spleen and these agonists then, in addition to phenylephrine, caused gradual and small increases in systemic arterial WBC concentrations. The increases in arterial RBC and WBC concentrations were abolished by transient isolation of the spleen from the systemic circulation. These three agents did not significantly modify differences between splenic venous and systemic arterial concentrations of PLT. 4. Intra-arterial injections of isoprenaline caused an increase in splenic diameter and a significant decrease in the splenic venous concentration of WBC, but barely influenced the veno-arterial differences in RBC and PLT concentrations across the spleen. 5. The present results indicate that contraction of the spleen through stimulation of splenic α1-adrenoceptors contributes to supplying RBC but not PLT into the systemic circulation, whereas splenic β-adrenoceptor activation leads to splenic dilatation with increased sequestration of WBC to the spleen despite no changes in the release of RBC and PLT from the spleen. |
| Databáze: | OpenAIRE |
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