Antiplasmodial activities of indole alkaloids from Tabernaemontana penduliflora K. Schum (Apocynaceae)
| Autor: | Alex de Théodore Atchadé, Dieudonné Emmanuel Pegnyemb, Dominique Serge Ngono Bikobo, Christian G. Bochet, André Néhémie Bitombo, Auguste Abouem A Zintchem, Norbert Mbabi Nyemeck |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Tabernaemontana
Phytochemicals Plasmodium falciparum 01 natural sciences Indole Alkaloids Antimalarials Corynanthe chemistry.chemical_compound Drug Discovery Cameroon Pharmacology Indole test Molecular Structure biology Apocynaceae Traditional medicine 010405 organic chemistry Alkaloid General Medicine Tabernaemontana penduliflora biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry visual_art Plant Bark visual_art.visual_art_medium SYBR Green I Bark |
| Zdroj: | Fitoterapia. 153:104941 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2021.104941 |
| Popis: | Five undescribed carboxy-indole alkaloids with corynanthe skeleton, penduflorines A–E (1–3) as well as a voacangine-N-oxide alkaloid, tabernaemontine (4), were isolated along with eight other known compounds (5–12) from the trunk bark of Tabernaemontana penduliflora K. Schum (Apocynaceae). Their structures were determined by means of spectroscopic and spectrometric methods such as UV, IR, NMR and HR-ESI-MS. Antiplasmodial activities of new isolates were evaluated against two strains of Plasmodium falciparum 3D7 and Dd2 by the Sybr green I-based fluorescence assay setup. Those compounds showed good in vitro activities. Among them, penduflorines A and B (1a and 1b) as well as tabernaemontine (4) showed significant inhibitory activities against the two strains with IC50 values ranged between 1.85 and 7.88 μg/mL. This is the first report of quaternary-N-indole alkaloids (1a, 1b, 2, 3a, 3b and 4) occurring in the form of zwitterion from Tabernaemontana genus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect