Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015

Autor:	Eunhee Kim, Shin Young Ryu, Won-Kyung Ho, Sang Jip Nam, Chulkyeong Han, Awadut G. Giri, Inho Yang, Hiyoung Kim, Jungwook Chin, Heonjoong Kang, Dong Hwan Won, Dongyup Hahn, Hyukjae Choi, Weihong Wang, Jihye Lee
Rok vydání:	2015
Předmět:	Stereochemistry Pharmaceutical Science Fungus Analytical Chemistry Benzophenones Inhibitory Concentration 50 Drug Discovery Insulin Secretion Ic50 values Acremonium sp. F9A015 Potassium Channel Blockers Molecule Animals Humans Insulin Nuclear Magnetic Resonance Biomolecular Pharmacology biology Molecular Structure Acremonium sp Insulin Secreting Cell Organic Chemistry biology.organism_classification Potassium channel Porifera Acremonium Sponge Complementary and alternative medicine Molecular Medicine Drug Screening Assays Antitumor
Zdroj:	Journal of natural products. 78(3)
ISSN:	1520-6025
Popis:	Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K(+) currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14edeed7fa6b26ff90c5c6dbea78061 https://pubmed.ncbi.nlm.nih.gov/25689430 Zobrazit plný text záznamu