Can we identify sources of fine particles responsible for exercise-induced ischemia on days with elevated air pollution? The ULTRA study
| Autor: | Timo Lanki, Nicole A.H. Janssen, Jeroen J. de Hartog, Juha Pekkanen, Annette Peters, Marko Vallius, Matthias Stölzel, Kirsi L. Timonen, Gerard Hoek, Esko Vanninen, Joachim Heinrich |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Ischemic Heart Diseases
vehicle emission Health Toxicology and Mutagenesis Cardiovascular health air pollution Myocardial Ischemia Ischemia Air pollution medicine.disease_cause soot Animal science cardiovascular disease Humans Medicine ST segment Particle Size Aged Air Pollutants business.industry Research Public Health Environmental and Occupational Health Odds ratio Middle Aged Particulates medicine.disease Air Pollution Cardiovascular Disease Elements Soot Vehicle Emission Confidence interval elements Exercise Test business |
| Zdroj: | Environ. Health Perspect. 114, 655-660 (2006) Environmental Health Perspectives |
| Popis: | Epidemiologic studies have shown that ambient particulate matter (PM) has adverse effects on cardiovascular health. Effective mitigation of the health effects requires identification of the most harmful PM sources. The objective of our study was to evaluate relative effects of fine PM [aero-dynamic diameter ≤ 2.5 μm (PM2.5)] from different sources on exercise-induced ischemia. We collected daily outdoor PM2.5 samples between autumn 1998 and spring 1999 in Helsinki, Finland. The mass of PM2.5 was apportioned between five sources. Forty-five elderly nonsmoking persons with stable coronary heart disease visited a clinic biweekly for submaximal exercise testing, during which the occurrence of ST segment depressions was recorded. Levels of PM2.5 originating from local traffic and long-range transport were associated with ST segment depressions > 0.1 mV, with odds ratios at 2-day lag of 1.53 [95% confidence interval (CI), 1.19-1.97] and 1.11 (95% CI, 1.02-1.20) per 1 μg/m3, respectively. In multipollutant models, where we used indicator elements for sources instead of source-specific PM2.5, only absorbance (elemental carbon), an indicator of local traffic and other combustion, was associated with ST segment depressions. Our results suggest that the PM fraction originating from combustion processes, notably traffic, exacerbates ischemic heart diseases associated with PM mass. |
| Databáze: | OpenAIRE |
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