Local esperience on frequency and significance of immunological overlap in the field of primary biliary cirrhosis (PBC)
| Autor: | Maurizio Picca, Gabriella Munegato, Simona Bollani, Caterina Defendenti, Simone Saibeni, Mariella Saudelli, Savino Bruno, Maria Sofia |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
biology
business.industry Autoantibody lcsh:QR1-502 Overlap syndromes Primary biliary cirrhosis Serum autoantibodies Autoimmunity Overlap syndrome General Medicine medicine.disease_cause medicine.disease Asymptomatic digestive system diseases lcsh:Microbiology Autoimmunity Liver disease Primary biliary cirrhosis Antigen Immunology medicine biology.protein medicine.symptom Antibody business |
| Zdroj: | Microbiologia Medica, Vol 23, Iss 2 (2008) |
| ISSN: | 2280-6423 |
| Popis: | The aim of this study was to investigate the frequency and quality of immunological overlap in serum AMA M2 positives. During the period January 2004 - December 2006, out of 3000 sera evaluated, 40 were AMA M2 positive. Six of these (15%) were without immunological overlap; they had clinical, histological and biochemical features of classical PBC with a normal length of life and ursodeoxycholic acid responding. In other 16 patients (40%), there was an association with antibody against antigens as SLA/LP, gp210 and Sp100, that causes the overlap syndrome AIH/PBC with various level of seriousness.The association with anti SLA/LP or with high level of autoantibody anti-Sp100 (index ELISA>10) waspresent in the patients investigated, as AIH type I°. Patients positive for anti gp210 with low anti-Sp100 index had instead a weak overlap AIH/PBC with slow evolving aspects. Nobody was positive for anti-LKM1, anti-LC, PML, or LBR.The remaining 45% of sera were positive for ANA, ENA,ANCA, with different clinical features. The antibody anti-SSARo52 and anti-centromere were frequent (17%) and modified the liver disease evolution.The most serious clinical case was a double overlap anti-centromere/SSARo52 with biochemical and histological AIH symptoms. Other ENA patterns did worsen the prognosis of PBC but showed or were associated with systemic diseases, often after a long asymptomatic period.The ANA IFI positive with a speckled pattern ENA negative, in other 7 patients (17%) worsened the long term prognosis because they expressed an overlap AIH/PBC with slowly evolving aspects.The most serious and intense clinical picture, with transplant perspective, was the association of the AMA M2 with anti Sp100 (index > 10) and pANNA. Four case were male (10%) but females were prevalent. |
| Databáze: | OpenAIRE |
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