Increase in basic fibroblast growth factor-like immunoreactivity in rat brain after forebrain ischemia
| Autor: | Kenji Takami, Yoshihiro Kiyota, Ryoichi Tsukuda, Akio Shino, Makoto Iwane, Masaomi Miyamoto, Akinobu Nagaoka |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Basic fibroblast growth factor Ischemia Hippocampus Biology Corpus callosum Fibroblast growth factor Brain ischemia chemistry.chemical_compound Reference Values Internal medicine Glial Fibrillary Acidic Protein medicine Animals Molecular Biology Temporal cortex General Neuroscience Putamen Brain Rats Inbred Strains medicine.disease Immunohistochemistry Temporal Lobe Rats Endocrinology nervous system chemistry Ischemic Attack Transient Fibroblast Growth Factor 2 Neurology (clinical) Developmental Biology |
| Zdroj: | Brain research. 545(1-2) |
| ISSN: | 0006-8993 |
| Popis: | Using immunohistochemical techniques, a study was conducted to determine whether basic fibroblast growth factor (bFGF) is generated as one of the ‘self-repair’ responses in rat brain following transient forebrain ischemia. In normal brain, slight bFGF-like immunoreactivity was observed. However, in rats exposed to 20 min of forebrain ischemia, intense bFGF-like immunoreactivity was observed in the CA1 subfield of the hippocampus and the caudate putamen, and marked activity was evident in the temporal cortex, corpus callosum and the CA4 subfield of the hippocampus. Marked neuronal degeneration was also observed in these brain regions following forebrain ischemia. These results suggest that induction of bFGF-like immunoreactivity may be related to the healing which follows brain ischemia. |
| Databáze: | OpenAIRE |
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