Serum concentrations of MCP-1 and IL-6 in combination predict the presence of coronary artery disease and mortality in subjects undergoing coronary angiography
| Autor: | Hamid Reza Rahimi, Elham Mohammadzadeh, Habibollah Esmaeily, Ali Taghipour, Latiffah A. Latiff, Maryam Mardan-Nik, Amir Avan, Parichehr Hanachi, Mohammad Tajfard, Gordon A. Ferns, Ahmad Sarreshtehdar Emrani, Mehdi Hasanzadeh, Majid Ghayour-Mobarhan, Sayed Reza Mirhafez, Mohsen Moohebati |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Clinical chemistry Clinical Biochemistry Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography Coronary artery disease Pathogenesis 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine Occlusion medicine Humans Molecular Biology Chemokine CCL2 Aged medicine.diagnostic_test business.industry Interleukin-6 Cell Biology General Medicine Middle Aged medicine.disease 030104 developmental biology medicine.anatomical_structure Predictive value of tests Angiography Cardiology Female business Lipid profile Artery |
| Zdroj: | Molecular and cellular biochemistry. 435(1-2) |
| ISSN: | 1573-4919 |
| Popis: | Cytokines play a key role in the pathogenesis of coronary artery disease (CAD). The aim of current study was to investigate the relationship between the serum concentrations of 12 cytokines with mortality and extent of CAD in individuals undergoing angiography and healthy controls. 342 CAD patients were recruited and divided into 2 groups: those with ≥50% occlusion in at least one coronary artery [Angiography (+)] or 2.16 pg/mL IL-6 had a > 94% sensitivity and 70% specificity in predicting 2 years mortality in the subjects with a serum MCP-1 > 61.95 pg/ mL, and patients having IL-6/MCP-1 combination had a shorter survival.Our findings demonstrate that CAD patients with serum MCP-1 and IL-6 levels of >61.95 and >2.16 pg/mL had a higher mortality with 94.1% sensitivity and 70.5% specificity for predicting mortality in CAD patients. |
| Databáze: | OpenAIRE |
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