Oxidative Stress in Patients with Chronic Hepatitis B and C
| Autor: | Ergul Belge Kurutas, Pinar Ciragil, Murat Aral, Omer Faruk Kokoglu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Antioxidant medicine.medical_treatment Hepatitis C virus lcsh:Medicine medicine.disease_cause Gastroenterology Pathogenesis Superoxide dismutase chemistry.chemical_compound Health Care Sciences and Services Internal medicine medicine Sağlık Bilimleri ve Hizmetleri biology business.industry lcsh:R Hepatitis B medicine.disease Malondialdehyde chemistry Catalase HBV HCV antioxidant enzymes malondialdehyde Immunology biology.protein business Oxidative stress |
| Zdroj: | Balkan Medical Journal, Vol 28, Iss 03, Pp 300-303 (2011) Volume: 2011, Issue: 3 300-303 Balkan Medical Journal |
| ISSN: | 2146-3131 2146-3123 |
| Popis: | Objective: Hepatitis B and hepatitis C virus infections are extensively seen throughout the world. Disturbances in the antioxidant system and oxidative stress may play a role in the pathogenesis of chronic liver diseases. The aim of this study was to evaluate the oxidant/antioxidant status in the serum of patients with chronic hepatitis B (CHB) and C (CHC). Material and Methods: Twenty patients with CHB, 20 with CHC and 30 healthy volunteers were included in this study. Catalase (CAT), superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels were measured in all patients and control group specthrophotometrically. Results: While CAT and SOD activities were significantly lower in patients with CHC, these enzymes were significantly higher in patients with CHB compared to controls. However, MDA levels were increased in each patient group as compared to the control group. Also, antioxidant enzyme activities were found to be significantly lower and MDA levels were higher in patients with CHC, compared to patients with CHB. Conclusion: We considered that insufficiency of antioxidant barrier may cause oxidative stress in patients with CHB and CHC, so antioxidant treatment should be useful for these patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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