Treatment Enhances Ultradian Rhythms of CSF Monoamine Metabolites in Patients with Major Depressive Episodes
| Autor: | Dennis E. Schmidt, John F Gouda, Benjamin W. Johnson, Richard Shiavi, Joseph Kwentus, John S. Kennedy, Ronald M. Salomon, Jennifer Urbano Blackford, Harry E. Gwirtsman |
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| Rok vydání: | 2005 |
| Předmět: |
Activity Cycles
Adult Male Serotonin medicine.medical_specialty Time Factors Dopamine Statistics as Topic chemistry.chemical_compound Internal medicine medicine Humans Biogenic Monoamines Circadian rhythm Ultradian rhythm Psychiatric Status Rating Scales Pharmacology Bupropion Depressive Disorder Major Chronobiology Sertraline Fourier Analysis Spectrum Analysis Homovanillic acid Tryptophan Homovanillic Acid Hydroxyindoleacetic Acid Middle Aged Antidepressive Agents Psychiatry and Mental health Monoamine neurotransmitter Endocrinology chemistry Area Under Curve Antidepressant Female Psychology medicine.drug |
| Zdroj: | Neuropsychopharmacology. 30:2082-2091 |
| ISSN: | 1740-634X 0893-133X |
| DOI: | 10.1038/sj.npp.1300746 |
| Popis: | Unipolar and bipolar depressions show abnormal behavioral manifestations of ultradian (less than 24 h) rhythms, but abnormal rhythms of the central neurotransmitters thought to be important for depression pathophysiology (eg dopamine (DA) and serotonin (5-HT)) have not been shown in this time frame. Since antidepressant treatments normalize disrupted rhythms in depression (eg rapid-eye-movement sleep and hormonal rhythms), we hypothesized that depression-related changes in ultradian oscillations of DA and 5-HT might be revealed during antidepressant treatment. Cerebrospinal fluid (CSF) samples collected q10 min for 24 h in 13 patients experiencing major depressive episodes (MDE) before and after treatment for 5 weeks with sertraline or bupropion were assayed for levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), and their ratio was calculated. Data were analyzed in the frequency domain using Fourier transforms and multivariate permutation testing. Antidepressant treatments were associated with decreased variance for 5-HIAA, increased variance for HVA, and markedly increased variance for the HVA : 5-HIAA ratio (p |
| Databáze: | OpenAIRE |
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