Prevalence and Clinical Relevance of IgE Sensitization to Profilin in Childhood: A Multicenter Study

Autor: Dondi, A, Tripodi, S, Panetta, V, Asero, R, Businco, Ad, Bianchi, A, Carlucci, A, Ricci, G, Bellini, F, Maiello, N, del Giudice, Mm, Frediani, T, Sodano, S, Dello Iacono, I, Macrì, F, Massaccesi, V, Caffarelli, C, Rinaldi, L, Patria, Mf, Varin, E, Peroni, Diego, Chinellato, I, Chini, L, Moschese, V, Lucarelli, S, Bernardini, R, Pingitore, G, Pelosi, U, Tosca, M, Paravati, F, La Grutta, S, Meglio, P, Calvani, M, Plebani, M, Matricardi, Pm
Přispěvatelé: Asero, Riccardo, Tripodi, Salvatore, Dondi, Arianna, Di Rienzo Businco, Andrea, Sfika, Ifigenia, Bianchi, Annamaria, Candelotti, Paolo, Caffarelli, Carlo, Povesi Dascola, Carlotta, Ricci, Giampaolo, Calamelli, Elisabetta, Maiello, Nunzia, MIRAGLIA DEL GIUDICE, Michele, Frediani, Tullio, Frediani, Simone, Macri, Francesco, Moretti, Matteo, Iacono, Iride Dello, Patria, Maria Francesca, Varin, Elena, Peroni, Diego, Comberiati, Pasquale, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Tosca, Mariangela, Cirisano, Anastasia, Faggian, Diego, Plebani, Mario, Verga, Carmen, Matricardi, Paolo Maria, Del Giudice, Michele Miraglia
Rok vydání: 2015
Předmět:
Male
Allergy
Profilin
Prevalence
Immunoglobulin E
Allergic rhinitis
Children
Component-resolved diagnosis
IgE
Oral allergy syndrome
Panallergens
Pollen
Allergens
Antigens
Plant
Carrier Proteins
Child
Cross Reactions
Cucumis sativus
Female
Fruit
Humans
Hypersensitivity
Italy
Poaceae
Profilins
Rhinitis
Allergic
Seasonal
Risk Factors
Skin Tests
Immunology and Allergy
Immunology
Medicine (all)
Epidemiology
Outpatient clinic
Sensitization
Rhinitis
Skin Test
biology
Allergen
food and beverages
General Medicine
medicine.anatomical_structure
Cross Reaction
Human
medicine.medical_specialty
Allergic rhinitis
Children
Component-resolved diagnosis
IgE
Oral allergy syndrome
Panallergens
Pollen
Profilin
Socio-culturale
macromolecular substances
Component-resolved diagnosi
Allergic
Allergic rhiniti
medicine
Antigens
Settore MED/38 - Pediatria Generale e Specialistica
Seasonal
business.industry
Risk Factor
Plant
medicine.disease
Cucumis sativu
biology.protein
Panallergen
Carrier Protein
business
Zdroj: International Archives of Allergy and Immunology. 168:25-31
ISSN: 1423-0097
1018-2438
DOI: 10.1159/000441222
Popis: Background: Little is known about the prevalence and clinical relevance of hypersensitivity to the plant panallergen profilin in children. Objectives: The present study aimed to investigate prevalence, risk factors and clinical relevance of profilin sensitization in a large cohort of Italian children of different ages living in different geographic areas. Methods: Children with pollen allergy enrolled by 16 pediatric outpatient clinics sited in three main geographic areas of Italy were studied. SPT were carried out with commercial pollen extracts and a commercial purified date palm pollen profilin. IgE specific for allergenic pollen molecules, Phl p 12 (grass profilin) and Pru p 3 (peach lipid transfer protein) were tested by ImmunoCAP FEIA. Results: IgE to Phl p 12 (≥0.35 kU/l) was observed in 296 of the 1,271 participants (23%), including 17 of the 108 (16%) preschool children. Profilin SPT was positive (≥3 mm) in 320/1,271 (25%) participants. The two diagnostic methods were concordant in 1,151 (91%, p < 0.0001) cases. Phl p 12 IgE prevalence declined from northern to southern Italy and was directly associated with IgE to Phl p 1 and/or Phl p 5 and Ole e 1. Among children with IgE to Phl p 12, OAS was provoked by kiwi, melon, watermelon, banana, apricot and cucumber. Conclusions: Profilin sensitization is very frequent among pollen-allergic children, occurs at a very young age and contributes to the development of childhood OAS with a typical pattern of offending foods. Pediatricians should always consider IgE sensitization to profilin while examining pollen-allergic children, even if they are at preschool age.
Databáze: OpenAIRE
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