Mutagenic evaluation of single cell protein with various mammalian test systems
| Autor: | H.W Renner, R Münzner |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Mice Inbred Strains Sister chromatid exchange Toxicology Chromosomes Mice Cricetulus Bacterial Proteins In vivo Cricetinae medicine Animals Cells Cultured Genes Dominant Cell Nucleus biology Chromosome biology.organism_classification Diet Rats Cell nucleus medicine.anatomical_structure Biochemistry Micronucleus test Single-cell protein Female Genes Lethal Bone marrow Bacteria Mutagens |
| Zdroj: | Toxicology. 10:141-150 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/0300-483x(78)90064-1 |
| Popis: | Single cell protein (SCP)--a product containing 80% raw protein obtained from bacteria grown on a methanol substrate--was tested for mutagenicity in 5 in vivo tests in different mammalian species. The animals were fed either a standard laboratory diet, a semi-synthetic diet, diets containing 12.5 and 25% SCP or pure SCP. The following investigations were carried out: dominant-lethal-test; host-mediated assay; micronucleus test; chromosome studies in bone marrow cells; in vivo sister chromatid exchange test. The statistical evaluation of all test results did not reveal any evidence for mutagenic activity of the SCP. |
| Databáze: | OpenAIRE |
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