Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity
| Autor: | Zhi-Kang Cai, Qiong Wang, Qi Chen, Zhong Wang, Huan Xu, Chong Liu, Xiang Wan, Yanbo Chen, Yu-Bing Peng, Meng Gu, Shi Fu, Juan Zhou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Stromal cell Prostatic Hyperplasia Diet High-Fat urologic and male genital diseases Article Cell Line 03 medical and health sciences 0302 clinical medicine Internal medicine Animals Humans Medicine Obesity Receptor Cell Proliferation Obese Mice Multidisciplinary Adiponectin urogenital system business.industry Cell Cycle Prostate ADIPONECTIN DEFICIENCY nutritional and metabolic diseases Hyperplasia medicine.disease Mice Inbred C57BL 030104 developmental biology Endocrinology Apoptosis 030220 oncology & carcinogenesis Disease Progression RNA Interference Receptors Adiponectin business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep43771 |
| Popis: | The incidence of benign prostatic hyperplasia (BPH) is increasing among obese individuals, but few studies have fully explained the underlying mechanisms. We aimed to elucidate the relationship between obesity and BPH. Herein, we show that in prostatic epithelial and stromal cells, adiponectin exerts multifunctional effects including anti-proliferation, blocking of G1/S-phase progression and the promotion of apoptosis via inhibiting the MEK-ERK-p90RSK axis. Furthermore, we found that a high-fat diet (HFD) led to adiponectin deficiency and microscopic BPH in a mouse model of obesity. And an adiponectin supplement protected the obese mice from microscopic BPH. The present study provides evidence that adiponectin is a protective regulator in the development and progression of BPH and that adiponectin deficiency causally links BPH with obesity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|