Clinical practice of rTMS reveals a functional dissociation between agency and hallucinations in schizophrenia

Autor: Pierre Thomas, Jean-Louis Goeb, Pierre Delion, Christine Delmaire, Bernard Lucas, Yvonne Delevoye-Turrell, Virginie Bulot, Renaud Jardri, Delphine Pins
Přispěvatelé: Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Neuro-anatomie fonctionnelle du comportement et de ses troubles, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR70-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR70-Université Pierre et Marie Curie - Paris 6 (UPMC), Université de Lille, CNRS, CHU Lille, Laboratoire de Neurosciences Fonctionnelles et Pathologies [LNFP], Unité de Recherche en Sciences Cognitives et Affectives [URECA], Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille]
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Male
medicine.medical_specialty
Hallucinations
Cognitive Neuroscience
medicine.medical_treatment
Experimental and Cognitive Psychology
Dissociative Disorders
Neuropsychological Tests
behavioral disciplines and activities
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
Delusion
Agency (sociology)
Image Processing
Computer-Assisted
medicine
Humans
Child
Antipsychotic
Psychiatry
Brain Mapping
self-awareness
agency
hallucinations
schizophrenia
motor control
rTMS
fMRI
Childhood-Onset Schizophrenia
medicine.disease
Magnetic Resonance Imaging
Transcranial Magnetic Stimulation
Electric Stimulation
030227 psychiatry
Oxygen
Clinical Practice
Schizophrenia
Acute dystonia
Schizophrenic Psychology
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Functional dissociation
medicine.symptom
Psychology
Schizophrenia
Childhood
030217 neurology & neurosurgery
Clinical psychology
Zdroj: Neuropsychologia
Neuropsychologia, 2008, 47 (1), pp.132-138. ⟨10.1016/j.neuropsychologia.2008.08.006⟩
Neuropsychologia, Elsevier, 2008, 47 (1), pp.132-138. ⟨10.1016/j.neuropsychologia.2008.08.006⟩
ISSN: 0028-3932
1873-3514
Popis: International audience; We report here the case of a hospitalized 11 year-old boy (YP) with a positive diagnosis of 'Childhood Onset Schizophrenia'. YP experienced verbal-auditory hallucinations, a delusion of alien control and hetero-aggressive behaviour. Antipsychotic drugs were unsuccessful and furthermore provoked severe acute dystonia. fMRI-guided rTMS applied over several cortical regions provided the means to reveal for the first time a functional dissociation between auditory-verbal hallucinations and agency. These results demonstrate the efficacy of rTMS for young patients suffering from drug-resistant hallucinations but they furthermore question the physiopathology of the hallucinatory process by suggesting that agency and hallucinations may be sub-served by different neural networks.
Databáze: OpenAIRE
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