Clinical practice of rTMS reveals a functional dissociation between agency and hallucinations in schizophrenia
Autor: | Pierre Thomas, Jean-Louis Goeb, Pierre Delion, Christine Delmaire, Bernard Lucas, Yvonne Delevoye-Turrell, Virginie Bulot, Renaud Jardri, Delphine Pins |
---|---|
Přispěvatelé: | Laboratoire de Neurosciences Fonctionnelles et Pathologies (LNFP), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Neuro-anatomie fonctionnelle du comportement et de ses troubles, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR70-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR70-Université Pierre et Marie Curie - Paris 6 (UPMC), Université de Lille, CNRS, CHU Lille, Laboratoire de Neurosciences Fonctionnelles et Pathologies [LNFP], Unité de Recherche en Sciences Cognitives et Affectives [URECA], Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille] |
Jazyk: | angličtina |
Rok vydání: | 2008 |
Předmět: |
Male
medicine.medical_specialty Hallucinations Cognitive Neuroscience medicine.medical_treatment Experimental and Cognitive Psychology Dissociative Disorders Neuropsychological Tests behavioral disciplines and activities 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Delusion Agency (sociology) Image Processing Computer-Assisted medicine Humans Child Antipsychotic Psychiatry Brain Mapping self-awareness agency hallucinations schizophrenia motor control rTMS fMRI Childhood-Onset Schizophrenia medicine.disease Magnetic Resonance Imaging Transcranial Magnetic Stimulation Electric Stimulation 030227 psychiatry Oxygen Clinical Practice Schizophrenia Acute dystonia Schizophrenic Psychology [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Functional dissociation medicine.symptom Psychology Schizophrenia Childhood 030217 neurology & neurosurgery Clinical psychology |
Zdroj: | Neuropsychologia Neuropsychologia, 2008, 47 (1), pp.132-138. ⟨10.1016/j.neuropsychologia.2008.08.006⟩ Neuropsychologia, Elsevier, 2008, 47 (1), pp.132-138. ⟨10.1016/j.neuropsychologia.2008.08.006⟩ |
ISSN: | 0028-3932 1873-3514 |
Popis: | International audience; We report here the case of a hospitalized 11 year-old boy (YP) with a positive diagnosis of 'Childhood Onset Schizophrenia'. YP experienced verbal-auditory hallucinations, a delusion of alien control and hetero-aggressive behaviour. Antipsychotic drugs were unsuccessful and furthermore provoked severe acute dystonia. fMRI-guided rTMS applied over several cortical regions provided the means to reveal for the first time a functional dissociation between auditory-verbal hallucinations and agency. These results demonstrate the efficacy of rTMS for young patients suffering from drug-resistant hallucinations but they furthermore question the physiopathology of the hallucinatory process by suggesting that agency and hallucinations may be sub-served by different neural networks. |
Databáze: | OpenAIRE |
Externí odkaz: |