Challenges in Interpretation of Diagnostic Test Results in a Mumps Outbreak in a Highly Vaccinated Population
| Autor: | Erik Kristjanson, D. Wallace, J. Gubbay, Tony Mazzulli, J. M. Walters, Lise Trotz-Williams, Nicola J. Mercer, K. Paphitis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male Pediatrics medicine.medical_specialty Adolescent 030106 microbiology Clinical Biochemistry Immunology Population Mumps Vaccine Disease Serology Disease Outbreaks 03 medical and health sciences Young Adult 0302 clinical medicine Diagnostic Laboratory Immunology Immunology and Allergy Medicine Humans 030212 general & internal medicine education Child Mumps Aged Immunoassay Ontario education.field_of_study business.industry Mumps outbreak Diagnostic Tests Routine Reverse Transcriptase Polymerase Chain Reaction Outbreak Diagnostic test Middle Aged Virology Vaccination Immunoglobulin M Molecular Diagnostic Techniques Mumps vaccine Child Preschool RNA Viral Female business |
| Popis: | In spite of a greatly reduced incidence rate due to vaccination, mumps outbreaks continue to occur in several areas of the world, sometimes in vaccinated populations. This article describes an outbreak in a highly vaccinated population in southwestern Ontario, Canada, and the challenges encountered in interpreting the results of diagnostic tests used in the outbreak. During the outbreak, patients were interviewed and classified according to the outbreak case definition, and specimens were collected for diagnostic testing according to Ontario guidelines. Twenty-seven individuals were classified as confirmed cases ( n = 19) or suspect cases ( n = 8) according to the case definition, only 9 of which were laboratory-confirmed cases: 7 confirmed by reverse transcriptase PCR (RT-PCR) and 2 by IgM serology. All 19 confirmed cases represented patients who were associated with secondary schools in the local area and had been vaccinated against mumps with one ( n = 2) or two ( n = 17) doses of the measles-mumps-rubella (MMR) vaccine. This is the first published report of an outbreak of mumps in Ontario in which all confirmed cases had been vaccinated against the disease. It highlights the limitations of and difficulties in interpreting current mumps diagnostic tests when used in vaccinated individuals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|