Copper-catalyzed dna damage by ascorbate and hydrogen peroxide: Kinetics and yield

Autor:	Walter A. Prütz, Reinhard Stoewe
Rok vydání:	1987
Předmět:	Free Radicals Hydroxyl Radical Chemistry DNA damage Radical Inorganic chemistry Kinetics chemistry.chemical_element Ascorbic Acid Hydrogen Peroxide Biochemistry Copper chemistry.chemical_compound Physiology (medical) Yield (chemistry) Hydroxides Hydroxyl radical Hydrogen peroxide DNA DNA Damage
Zdroj:	Free Radical Biology and Medicine. 3:97-105
ISSN:	0891-5849
DOI:	10.1016/s0891-5849(87)80003-5
Popis:	Time profiles for degradation of DNA via reaction of H2O2 with the DNA-Cu+ complex were analyzed over a wide range of concentrations of the components. The yield of DNA damage per H2O2 molecule is 10 times lower than that obtained with gamma-radiolytically generated .OH radicals. The observations can be explained by a model in which H2O2 reacts, slowly on the one hand with DNA-Cu+ by formation of toxic .OH radicals immediately at the DNA and faster on the other hand with Cu+ in the bulk solution by formation of less toxic Cu(III) intermediates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a143a9fd8855c6dbc60d3c7a05573c08 https://doi.org/10.1016/s0891-5849(87)80003-5 Zobrazit plný text záznamu