Travel-Associated Zika Virus Disease Acquired in the Americas Through February 2016: A GeoSentinel Analysis
| Autor: | Davidson H, Hamer, Kira A, Barbre, Lin H, Chen, Martin P, Grobusch, Patricia, Schlagenhauf, Abraham, Goorhuis, Perry J J, van Genderen, Israel, Molina, Hilmir, Asgeirsson, Phyllis E, Kozarsky, Eric, Caumes, Stefan H, Hagmann, Frank P, Mockenhaupt, Gilles, Eperon, Elizabeth D, Barnett, Emmanuel, Bottieau, Andrea K, Boggild, Philippe, Gautret, Noreen A, Hynes, Susan, Kuhn, R Ryan, Lash, Karin, Leder, Michael, Libman, Denis J M, Malvy, Cecilia, Perret, Camilla, Rothe, Eli, Schwartz, Annelies, Wilder-Smith, Martin S, Cetron, Douglas H, Esposito, Henry, Wu |
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| Přispěvatelé: | Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Department of Epidemiology and Preventive Medicine, Monash University, Victoria, Australia, Monash University [Clayton], Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires (PPSM), École normale supérieure - Cachan (ENS Cachan)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), AII - Infectious diseases, APH - Global Health, Infectious diseases, APH - Aging & Later Life, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), University of Zurich, Hamer, Davidson H, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
| Rok vydání: | 2016 |
| Předmět: |
Zika virus disease
Adult Male medicine.medical_specialty Adolescent 030231 tropical medicine 610 Medicine & health Signs and symptoms Guillain-Barre Syndrome Dengue fever Zika virus 03 medical and health sciences Young Adult 0302 clinical medicine Infectious Epidemiology [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Pregnancy Epidemiology Internal Medicine Medicine Travel medicine Humans 030212 general & internal medicine Pregnancy Complications Infectious Child Aged Travel Hematologic tests biology business.industry Zika Virus Infection Central America 10060 Epidemiology Biostatistics and Prevention Institute (EBPI) General Medicine Middle Aged South America medicine.disease biology.organism_classification Virology 3. Good health Caribbean Region 2724 Internal Medicine Child Preschool Female business Sentinel Surveillance |
| Zdroj: | Annals of Internal Medicine Annals of Internal Medicine, American College of Physicians, 2017, 166 (2), pp.99+. ⟨10.7326/M16-1842⟩ Annals of internal medicine, 166(2), 99-108. American College of Physicians Annals of Internal Medicine, 2017, 166 (2), pp.99+. ⟨10.7326/M16-1842⟩ |
| ISSN: | 1539-3704 0003-4819 |
| DOI: | 10.7326/M16-1842⟩ |
| Popis: | International audience; Background: Zika virus has spread rapidly in the Americas and has been imported into many nonendemic countries by travelers. Objective: To describe clinical manifestations and epidemiology of Zika virus disease in travelers exposed in the Americas. Design: Descriptive, using GeoSentinel records. Setting: 63 travel and tropical medicine clinics in 30 countries. Patients: Ill returned travelers with a confirmed, probable, or clinically suspected diagnosis of Zika virus disease seen between January 2013 and 29 February 2016. Measurements: Frequencies of demographic, trip, and clinical characteristics and complications. Results: Starting in May 2015, 93 cases of Zika virus disease were reported. Common symptoms included exanthema (88%), fever (76%), and arthralgia (72%). Fifty-nine percent of patients were exposed in South America; 71% were diagnosed in Europe. Case status was established most commonly by polymerase chain reaction (PCR) testing of blood and less often by PCR testing of other body fluids or serology and plaque-reduction neutralization testing. Two patients developed Guillain-Barre syndrome, and 3 of 4 pregnancies had adverse outcomes (microcephaly, major fetal neurologic abnormalities, and intrauterine fetal death). Limitation: Surveillance data collected by specialized clinics may not be representative of all ill returned travelers, and denominator data are unavailable. Conclusion: These surveillance data help characterize the clinical manifestations and adverse outcomes of Zika virus disease among travelers infected in the Americas and show a need for global standardization of diagnostic testing. The serious fetal complications observed in this study highlight the importance of travel advisories and prevention measures for pregnant women and their partners. Travelers are sentinels for global Zika virus circulation and may facilitate further transmission. |
| Databáze: | OpenAIRE |
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