Prognosis following local recurrence after breast conserving treatment in young women with early breast cancer
| Autor: | Adri C. Voogd, Philip Poortmans, S.W.M. Scheepers, M.J.C. van der Sangen, Bea Martine Desiree Lemaire, Vivianne C. G. Tjan-Heijnen, C.L.H. van Berlo |
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| Přispěvatelé: | Interne Geneeskunde, Epidemiologie, RS: CAPHRI School for Public Health and Primary Care, RS: GROW - School for Oncology and Reproduction |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Reoperation Oncology medicine.medical_specialty Time Factors Multivariate analysis Breast imaging medicine.medical_treatment Breast Neoplasms Mastectomy Segmental Risk Assessment Disease-Free Survival Cohort Studies Breast cancer Internal medicine Confidence Intervals medicine Local recurrence Humans Registries Stage (cooking) Survival rate Early Detection of Cancer Neoplasm Staging Proportional Hazards Models Retrospective Studies Early breast cancer business.industry Hazard ratio Age Factors General Medicine Breast conservation Middle Aged Prognosis medicine.disease Survival Analysis Radiation therapy Treatment Outcome Multivariate Analysis Female Surgery Neoplasm Recurrence Local business |
| Zdroj: | European Journal of Surgical Oncology, 39(8), 892-898. ELSEVIER SCI LTD |
| ISSN: | 1532-2157 0748-7983 |
| Popis: | Background Few studies have focussed on the prognosis of young women with local recurrence (LR) after breast-conserving therapy and the factors that can be used to predict their prognosis. Methods We studied the outcome and related prognostic factors in 124 patients with an isolated local recurrence in the breast following breast-conserving surgery and radiotherapy for early stage breast cancer diagnosed at the age of 40 years or younger. Results The median follow-up of the patients after diagnosis of LR was 7.0 years. At 10 years from the date of salvage treatment, the overall survival rate was 73% (95% CI, 63–83), the distant recurrence-free survival rate was 61% (95% CI, 53–73), and the local control rate (i.e. survival without subsequent LR or local progression) was 95% (95% CI, 91–99). In the multivariate analysis, the risk of distant metastases also tended to be higher for patients with LR occurring within 5 years after BCT, as compared to patients with LR more than 5 years after BCT (Hazard ratio [HR], 1.89; p = 0.09). A worse distant recurrence-free survival was also observed for patients with a LR measuring more than 2 cm in diameter, compared to those with a LR of 2 cm or smaller (HR, 2.88; p = 0.007), and for patients with a LR causing symptoms or suspicious findings at clinical breast examination, compared to those with a LR detected by breast imaging only (HR 3.70; p = 0.03). Conclusions These results suggest that early detection of LR after BCT in young women can improve treatment outcome. |
| Databáze: | OpenAIRE |
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