Increase in superoxide dismutase after cerebrovascular accident
| Autor: | M. Barak, O. Gozlan, N. Gruener, B. Gross |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Pathology Free Radicals Enolase General Biochemistry Genetics and Molecular Biology Brain Ischemia Superoxide dismutase Pathogenesis Central nervous system disease Brain ischemia Cerebrospinal fluid Internal medicine medicine Humans General Pharmacology Toxicology and Pharmaceutics Stroke Aged Aged 80 and over chemistry.chemical_classification Reactive oxygen species L-Lactate Dehydrogenase biology Superoxide Dismutase business.industry General Medicine Middle Aged medicine.disease Cerebrovascular Disorders Endocrinology chemistry Case-Control Studies Phosphopyruvate Hydratase biology.protein Reactive Oxygen Species business |
| Zdroj: | Life Sciences. 54:711-713 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(94)90159-7 |
| Popis: | Superoxide dismutase (SOD), neuron specific enolase (NSE) and lactic dehydrogenase (LDH) were measured in the serum and cerebrospinal fluid (CSF) of ischemic cerebrovascular patients, other neurological patients and in age-matched healthy controls (serum only). The levels of SOD in the CSF or serum of the ischemic patients in the first 24 hrs after stroke were similar to the control groups. However, SOD levels in the ischemic patients increased after two days, reaching their peak values after one week (2-3 fold of the initial values). NSE showed a similar kinetics while LDH showed no change. These results suggest that oxygen radicals are formed in the ischemic patients and the increased synthesis of SOD may protect the patients from the potential damage of such radicals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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