Prevalence and risk factors of poor immune recovery among adult HIV patients attending care and treatment centre in northwestern Tanzania following the use of highly active antiretroviral therapy: a retrospective study
| Autor: | Erasmus Kamugisha, Daniel W. Gunda, Bonaventura C.T. Mpondo, Engelbert Z. Rauya, Semvua B. Kilonzo |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Pediatrics Human immunodeficiency virus (HIV) lcsh:Medicine HIV Infections medicine.disease_cause Tanzania 0302 clinical medicine Risk Factors Antiretroviral Therapy Highly Active Prevalence 030212 general & internal medicine Immune recovery lcsh:QH301-705.5 Northwestern Tanzania biology General Medicine Middle Aged Antiretroviral therapy Host-Pathogen Interactions Female Research Article Adult medicine.medical_specialty Anti-HIV Agents General Biochemistry Genetics and Molecular Biology World health Young Adult 03 medical and health sciences Acquired immunodeficiency syndrome (AIDS) medicine Humans lcsh:Science (General) Retrospective Studies Acquired Immunodeficiency Syndrome business.industry lcsh:R HIV Retrospective cohort study biology.organism_classification medicine.disease 030112 virology CD4 Lymphocyte Count lcsh:Biology (General) Immunology HIV-1 Hiv patients business lcsh:Q1-390 |
| Zdroj: | BMC Research Notes, Vol 10, Iss 1, Pp 1-6 (2017) BMC Research Notes |
| ISSN: | 1756-0500 |
| DOI: | 10.1186/s13104-017-2521-0 |
| Popis: | Background Highly Active Antiretroviral therapy (HAART) reverses the effect of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) by durably suppressing viral replication. This allows CD4 gain to levels that are adequate enough to restore the body’s capability to fight against opportunistic infections (OIs). Patients with poor immune recovery have been shown to have higher risk of developing both AIDS and non AIDS related clinical events. This study aimed at assessing the proportions and risk factors of poor immune recovery in adult HIV-infected patients on 48 months of HAART attending care and treatment center (CTC) in northwestern Tanzania. Methods A retrospective analysis of adult HIV patients’ data attending CTC at Sekou Toure hospital and who initiated HAART between February 2004 and January 2008 was done. Poor immune recovery was defined as a CD4 count less than 350 cells/µl on follow up as used in other studies. Results A total of 734 patients were included in the study. In this study 50.25% of patients attending CTC at Sekou Toure hospital were found to have poor immune recovery. The risk of developing inadequate immune recovery was independently associated with male gender, age older than 50 years, low baseline CD4 counts, and advanced World Health Organization (WHO) clinical stage. Conclusions Poor immune recovery is prevalent among adult HIV patients attending CTC at Sekou Toure hospital in Northwestern part of Tanzania and opportunistic infections are common in this sub group of patients. Clinicians in resource limited countries need to identify these patients timely and plan them for targeted viral assessment and close clinical follow up to improve their long term clinical outcome. |
| Databáze: | OpenAIRE |
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