Management of Ponatinib in Patients with Chronic Myeloid Leukemia with Cardiovascular Risk Factors
| Autor: | Giuseppina Novo, Marco Santoro, Vincenzo Accurso, Antonio Russo, Alessandro Perez, Angelo Davide Contrino, Sergio Siragusa, Salvatrice Mancuso, Florinda Di Piazza, Mariano Sardo |
|---|---|
| Přispěvatelé: | Santoro, Marco, Accurso, Vincenzo, Mancuso, Salvatrice, Contrino, Angelo Davide, Sardo, Mariano, Novo, Giuseppina, Di Piazza, Florinda, Perez, Alessandro, Russo, Antonio, Siragusa, Sergio |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.drug_class 030106 microbiology Cardiovascular risk factors Type 2 diabetes Disease Tyrosine-kinase inhibitor Settore MED/15 - Malattie Del Sangue 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Drug Discovery medicine Pharmacology (medical) In patient Adverse effect Pharmacology business.industry Ponatinib Chronic myeloid leukemia Myeloid leukemia General Medicine medicine.disease Cardiovascular risk Infectious Diseases Oncology chemistry 030220 oncology & carcinogenesis business |
| Popis: | Cardiovascular (CV) adverse events are considered common complications of ponatinib treatment. Recently, it has been demonstrated that ponatinib dose reductions in definite settings can obtain optimal responses and lower ponatinib-related CV events. In this study, we describe the management of 5 patients with chronic myeloid leukemia treated with ponatinib, from second to fourth line of tyrosine kinase inhibitor therapy, carrying high pre-ponatinib CV risk, who obtained optimal molecular response and developed no CV adverse event during follow-up. Among these 5 patients, 2 had diagnosis of ischemic heart disease and underwent percutaneous angioplasty, 2 had type 2 diabetes and arterial hypertension, and 1 had only arterial hypertension. Median follow-up for ponatinib therapy is 1,039 days (34.6 months). Median dosage administered is 30 mg a day. SCORE charts were used to estimate risk of CV death in 10 years and Charlson Comorbidity Index was applied to estimate age-adjusted risk of death related to comorbidities. Strict cardiologic follow-up (complete evaluation every 3 to 6 months) and maximum effort in the control of CV modifiable risk factors are strongly recommended in the management of ponatinib treatment in patients at high risk for CV events and may allow the use of ponatinib in patients belonging to CV risk category. |
| Databáze: | OpenAIRE |
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