Patuletin acetylrhamnosides from Kalanchoe brasiliensis as inhibitors of human lymphocyte proliferative activity
| Autor: | Sônia Soares Costa, V.L.G. Moraes, and Akino Jossang, Bernard Bodo, M. L. M. Souza |
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| Rok vydání: | 1994 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry Rhamnose Kalanchoe brasiliensis Pharmaceutical Science Biology Lymphocyte Activation Molecular conformation Analytical Chemistry chemistry.chemical_compound Structure-Activity Relationship Drug Discovery Humans Spectral analysis Glycosides Pharmacology Human lymphocyte Plants Medicinal Molecular Structure Plant Stems Plant Extracts Organic Chemistry Kalanchoe biology.organism_classification Plant Leaves Complementary and alternative medicine chemistry Biochemistry Chromones Patuletin Molecular Medicine |
| Zdroj: | Journal of natural products. 57(11) |
| ISSN: | 0163-3864 |
| Popis: | The fractionation of the juice of fresh stems and leaves of Kalanchoe brasiliensis was monitored by an assay measuring lymphocyte proliferative activity and allowed the isolation and identification of seven patuletin rhamnoside derivatives [1-7]. Three of them are novel, namely, patuletin 3-O-(4"-O-acetyl-alpha-L-rhamnopyranosyl)-7-O-(2'"-O-acetyl- alpha-L-rhamnopyranoside) [1], patuletin 3-O-alpha-L-rhamnopyranosyl-7-O-(2'"-O-acetyl-alpha-L- rhamnopyranoside) [3], and patuletin 3-O-(4"-O-acetyl-alpha-L-rhamnopyranosyl)-7-O- rhamnopyranoside [4], and four are known [2, 5-7]. Their structures were determined by the analysis of 1H-1H and 1H-13C COSY nmr, ci, and fab mass spectra. |
| Databáze: | OpenAIRE |
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