Plasma serine in schizophrenics and controls measured by gas chromatography-mass spectrometry
| Autor: | Sankar Baruah, Rafiq Waziri, Teki S. Hegwood, Larry M. Mallis |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Psychiatric Status Rating Scales chemistry.chemical_classification Chromatography Glycine Plasma Mass spectrometry Control subjects Gas Chromatography-Mass Spectrometry Amino acid Serine Psychiatry and Mental health chemistry Schizophrenia Humans Female Schizophrenic Psychology Gas chromatography Gas chromatography–mass spectrometry Biological Psychiatry Antipsychotic Agents |
| Zdroj: | Psychiatry Research. 37:261-270 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/0165-1781(91)90062-t |
| Popis: | In several previous studies, we reported significantly higher plasma serine concentrations in psychotic (and schizophrenic) subjects compared with nonpsychotic and control subjects. In those studies, we used a gas chromatopgraphy technique to assay the amino acids. Perry and Hanson (1985), using cation-exchange chromatography to assay plasma amino acids, found no differences in the plasma serine concentrations of controls compared with schizophrenic patients. They criticized our work on technical grounds and suggested that some other substance was co-eluting with the gas chromatographic serine. peaks in our assays. We have now examined the plasma of schizophrenic and control subjects with gas chromatography-mass spectrometry (GC-MS), where accurate amino acid quantitation relative to a known internal standard can be achieved. The results show that the plasma serine concentrations of schizophrenic patients are segnificantly higher than those of controls. Also, plasma glycine concentrations are significantly higher in schizophrenic patients compared with controls. |
| Databáze: | OpenAIRE |
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